4j9j

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'''Unreleased structure'''
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{{STRUCTURE_4j9j| PDB=4j9j | SCENE= }}
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===Structure of designed HisF===
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{{ABSTRACT_PUBMED_23806364}}
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The entry 4j9j is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/HIS6_THEMA HIS6_THEMA]] IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.[HAMAP-Rule:MF_01013]
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Authors: Sterner, R., Rajendran, C., Sperl, J.
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==About this Structure==
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[[4j9j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima_msb8 Thermotoga maritima msb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J9J OCA].
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Description: Structure of designed HisF
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==Reference==
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<ref group="xtra">PMID:023806364</ref><references group="xtra"/><references/>
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[[Category: Thermotoga maritima msb8]]
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[[Category: Rajendran, C.]]
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[[Category: Sperl, J.]]
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[[Category: Sterner, R.]]
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[[Category: Beta barrel]]
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[[Category: Lyase]]
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[[Category: Protein engineering]]

Revision as of 04:57, 18 July 2013

Template:STRUCTURE 4j9j

Contents

Structure of designed HisF

Template:ABSTRACT PUBMED 23806364

Function

[HIS6_THEMA] IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.[HAMAP-Rule:MF_01013]

About this Structure

4j9j is a 1 chain structure with sequence from Thermotoga maritima msb8. Full crystallographic information is available from OCA.

Reference

  • Sperl JM, Rohweder B, Rajendran C, Sterner R. Establishing catalytic activity on an artificial (betaalpha)-barrel protein designed from identical half-barrels. FEBS Lett. 2013 Jun 24. pii: S0014-5793(13)00469-9. doi:, 10.1016/j.febslet.2013.06.022. PMID:23806364 doi:10.1016/j.febslet.2013.06.022

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