4jk6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4jk6| PDB=4jk6 | SCENE= }}
 +
===Human urokinase-type Plasminogen Activator (uPA) in complex with a bicyclic peptide inhibitor (UK18-D-Aba)===
 +
{{ABSTRACT_PUBMED_23828687}}
-
The entry 4jk6 is ON HOLD
+
==Disease==
 +
[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[http://omim.org/entry/601709 601709]]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
-
Authors: Buth, S.A., Leiman, P.G., Chen, S., Heinis, C.
+
==Function==
 +
[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
-
Description: Human urokinase-type Plasminogen Activator (uPA) in complex with a bicyclic peptide inhibitor (UK18-D-Aba)
+
==About this Structure==
 +
[[4jk6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JK6 OCA].
 +
 
 +
==Reference==
 +
<ref group="xtra">PMID:023828687</ref><references group="xtra"/><references/>
 +
[[Category: Homo sapiens]]
 +
[[Category: U-plasminogen activator]]
 +
[[Category: Buth, S A.]]
 +
[[Category: Chen, S.]]
 +
[[Category: Heinis, C.]]
 +
[[Category: Leiman, P G.]]
 +
[[Category: Bicyclic peptide inhibitor]]
 +
[[Category: Chymotrypsin fold]]
 +
[[Category: D-amino acid]]
 +
[[Category: Hydrolase-hydrolase inhibitor complex]]
 +
[[Category: Serine protease]]
 +
[[Category: Urokinase-type plasminogen activator]]

Revision as of 05:01, 18 July 2013

Template:STRUCTURE 4jk6

Contents

Human urokinase-type Plasminogen Activator (uPA) in complex with a bicyclic peptide inhibitor (UK18-D-Aba)

Template:ABSTRACT PUBMED 23828687

Disease

[UROK_HUMAN] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:601709]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.[1]

Function

[UROK_HUMAN] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

About this Structure

4jk6 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Chen S, Gfeller D, Buth SA, Michielin O, Leiman PG, Heinis C. Improving Binding Affinity and Stability of Peptide Ligands by Substituting Glycines with D-Amino Acids. Chembiochem. 2013 Jul 4. doi: 10.1002/cbic.201300228. PMID:23828687 doi:10.1002/cbic.201300228
  1. ↑ Paterson AD, Rommens JM, Bharaj B, Blavignac J, Wong I, Diamandis M, Waye JS, Rivard GE, Hayward CP. Persons with Quebec platelet disorder have a tandem duplication of PLAU, the urokinase plasminogen activator gene. Blood. 2010 Feb 11;115(6):1264-6. doi: 10.1182/blood-2009-07-233965. Epub 2009, Dec 9. PMID:20007542 doi:10.1182/blood-2009-07-233965

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4jk6"
Personal tools