4kk0

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'''Unreleased structure'''
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{{STRUCTURE_4kk0| PDB=4kk0 | SCENE= }}
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===Crystal Structure of TSC1 core domain from S. pombe===
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The entry 4kk0 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/TSC1_SCHPO TSC1_SCHPO]] Together with tsc2, required for uptake of various amino-acids from the environment and for proper conjugation. Involved in induction of gene expression of permeases and genes required for meiosis upon nitrogen starvation. May act as a GTPase-activating protein (GAP) for the small GTPase rhb1.<ref>PMID:12136010</ref> <ref>PMID:14718525</ref> <ref>PMID:16624901</ref>
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Authors: Sun, W., Zhu, Y., Wang, Z.Z., Zhong, Q., Gao, F., Lou, J.Z., Gong, W.M., Xu, W.Q.
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==About this Structure==
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[[4kk0]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KK0 OCA].
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Description: Crystal Structure of TSC1 core domain from S. pombe
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Schizosaccharomyces pombe 972h-]]
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[[Category: Gao, F.]]
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[[Category: Gong, W M.]]
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[[Category: Lou, J Z.]]
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[[Category: Sun, W.]]
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[[Category: Wang, Z Z.]]
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[[Category: Xu, W Q.]]
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[[Category: Zhong, Q.]]
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[[Category: Zhu, Y.]]
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[[Category: Heat repeat]]
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[[Category: Immune system]]
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[[Category: Tumor suppressor]]

Revision as of 05:12, 18 July 2013

Template:STRUCTURE 4kk0

Contents

Crystal Structure of TSC1 core domain from S. pombe

Function

[TSC1_SCHPO] Together with tsc2, required for uptake of various amino-acids from the environment and for proper conjugation. Involved in induction of gene expression of permeases and genes required for meiosis upon nitrogen starvation. May act as a GTPase-activating protein (GAP) for the small GTPase rhb1.[1] [2] [3]

About this Structure

4kk0 is a 10 chain structure with sequence from Schizosaccharomyces pombe 972h-. Full crystallographic information is available from OCA.

Reference

  1. ↑ Matsumoto S, Bandyopadhyay A, Kwiatkowski DJ, Maitra U, Matsumoto T. Role of the Tsc1-Tsc2 complex in signaling and transport across the cell membrane in the fission yeast Schizosaccharomyces pombe. Genetics. 2002 Jul;161(3):1053-63. PMID:12136010
  2. ↑ van Slegtenhorst M, Carr E, Stoyanova R, Kruger WD, Henske EP. Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe. J Biol Chem. 2004 Mar 26;279(13):12706-13. Epub 2004 Jan 12. PMID:14718525 doi:10.1074/jbc.M313874200
  3. ↑ Nakase Y, Fukuda K, Chikashige Y, Tsutsumi C, Morita D, Kawamoto S, Ohnuki M, Hiraoka Y, Matsumoto T. A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex. Genetics. 2006 Jun;173(2):569-78. Epub 2006 Apr 19. PMID:16624901 doi:10.1534/genetics.106.056895

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