Diphtheria toxin repressor (DtxR) is an iron-dependent repressor which is synthesized by the diphtheria bacterium when it is in iron-poor environment. DtxR structure contains a DNA-binding domain (DBD) containing the hlix-turn-helix motif at the N-terminal, an interface domain containing the metal-binding sites and a flexible C-terminal. The DtxR regulates the expression of high affinity iron uptake system.
3D structures of diphtheria toxin repressor
Updated on 21-July-2013
1dpr, 1bi1, 1bi2 – CdDtxR – Corynebacterium diphtheriae
1g3s, 1g3t, 1p92 – CdDtxR (mutant)
1bym, 1qvp, 1qw1 – CdDtxR C terminal - NMR
DtxR complex with metal
2dtr – CdDtxR + Co
1bi3, 1bi0 – CdDtxR + Zn
1fwz, 1g3y – CdDtxR (mutant) + Zn
2tdx, 1xcv, 2qq9, 2qqa, 2qqb, 3glx – CdDtxR (mutant) + Ni
1g3w – CdDtxR (mutant) + Cd
DtxR complex with metal and DNA
1ddn, 1f5t – CdDtxR (mutant) + Ni + DNA
1c0w – CdDtxR + Co + DNA
