Arginine repressor (ArgR) is a prokaryotic repressor which regulates the arginine deiminase pathway. In this pathway, arginine is metabolized to form ammonia, CO2 and ATP. The ArgR releases the expression of the arginine deiminase pathway in the presence of arginine. The genes controlled by ArgR are not found in a single operon. While repressors are usually active as dimers, ArgR is a hexamer and binds to 2 palindromic DNA sites. The structure of ArgR shows a DNA-binding domain at the N-terminal and a C-terminal domain which contains the intersubunit interaction sites and the Arg binding site.
3D structures of arginine repressor
Updated on 22-July-2013
Arginine repressor
1b4a – GsArgR – Geobacillus stearothermophilus
1f9n – BsArgR – Bacillus subtilis
3v4g – ArgR – Vibrio vulnificus
3ere – MtArgR + DNA – Mycobacterium tuberculosis
3fhz, 3laj – MtArgR + DNA + Arg
3lap – MtArgR + DNA + canavanine
Arginine repressor N terminal
1aoy – EcArgR N terminal - Escherichia coli - NMR
1b4b – BsArgR N terminal
2p5l – BsArgR N terminal + DNA
Arginine repressor C terminal
1xxc – EcArgR C terminal
2p5k – GsArgR C terminal
3bue – MtArgR C terminal
1xxb – EcArgR C terminal + Arg
1xxa, 1xxb – EcArgR C terminal + Arg
2p5m – BsArgR C terminal (mutant) + Arg
2zfz, 3cag – MtArgR C terminal + Arg
