Sandbox 126

From Proteopedia

proteopedia linkproteopedia link

Revision as of 18:40, 23 July 2013 (edit) Allison Granberry (Talk | contribs) (→Introduction) ← Previous diff		Revision as of 18:44, 23 July 2013 (edit) (undo) Allison Granberry (Talk | contribs) Next diff →
Line 2:		Line 2:
	==Background==		==Background==
-		+	PBP2a is composed of two domains: a non-penicillin binding ('''NPB''') domain and a '''TP''' domain. The NBP domain of PBP2a is anchored in the cell membrane, while the TP domain “sits” in the periplasm with its active site facing the inner surface of the cell wall. The active site contains a serine residue at position 403 ('''Ser403''') which catalyzes the cross-linking of the peptidoglycan rows with pentaglycine cross-links.
-		+
-		+
-		+
-		+
-		+
-		+
	==Catalytic Mechanism of PBP2a==		==Catalytic Mechanism of PBP2a==

---

Revision as of 18:44, 23 July 2013

spinqualitylabelsall models Structure of PBP2a Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Background

PBP2a is composed of two domains: a non-penicillin binding (NPB) domain and a TP domain. The NBP domain of PBP2a is anchored in the cell membrane, while the TP domain “sits” in the periplasm with its active site facing the inner surface of the cell wall. The active site contains a serine residue at position 403 (Ser403) which catalyzes the cross-linking of the peptidoglycan rows with pentaglycine cross-links.

Catalytic Mechanism of PBP2a