4hlz
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
[[4hlz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/japan/305/1957(h2n2)) Influenza a virus (a/japan/305/1957(h2n2))] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLZ OCA]. | [[4hlz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/japan/305/1957(h2n2)) Influenza a virus (a/japan/305/1957(h2n2))] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLZ OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023552413</ref><references group="xtra"/><references/> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Dreyfus, C.]] | [[Category: Dreyfus, C.]] | ||
Revision as of 11:02, 24 July 2013
Contents |
Crystal Structure of Fab C179 in Complex with a H2N2 influenza virus hemagglutinin
Template:ABSTRACT PUBMED 23552413
Function
[C7S226_I57A0] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643]
About this Structure
4hlz is a 12 chain structure with sequence from Influenza a virus (a/japan/305/1957(h2n2)) and Mus musculus. Full crystallographic information is available from OCA.
Reference
- Dreyfus C, Ekiert DC, Wilson IA. Structure of a classical broadly neutralizing stem antibody in complex with a pandemic H2 hemagglutinin. J Virol. 2013 Apr 3. PMID:23552413 doi:10.1128/JVI.02975-12
