3zhf

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{{STRUCTURE_3zhf| PDB=3zhf | SCENE= }}
{{STRUCTURE_3zhf| PDB=3zhf | SCENE= }}
===gamma 2 adaptin EAR domain crystal structure with preS1 site1 peptide NPDWDFN===
===gamma 2 adaptin EAR domain crystal structure with preS1 site1 peptide NPDWDFN===
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{{ABSTRACT_PUBMED_23851574}}
==Function==
==Function==
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==Reference==
==Reference==
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<references group="xtra"/><references/>
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<ref group="xtra">PMID:023851574</ref><references group="xtra"/><references/>
[[Category: Ashcroft, A.]]
[[Category: Ashcroft, A.]]
[[Category: Ferguson, N.]]
[[Category: Ferguson, N.]]

Revision as of 11:09, 24 July 2013

Template:STRUCTURE 3zhf

Contents

gamma 2 adaptin EAR domain crystal structure with preS1 site1 peptide NPDWDFN

Template:ABSTRACT PUBMED 23851574

Function

[AP1G2_HUMAN] May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV).[1] [2] [3] [Q67953_HBV] The middle envelope protein plays an important role in the budding of the virion. It is involved in the induction of budding in a nucleocapsid independent way. In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid (By similarity).[SAAS:SAAS000349_004_055156]

About this Structure

3zhf is a 2 chain structure with sequence from Escherichia coli bl21(de3). Full crystallographic information is available from OCA.

Reference

  • Jurgens MC, Voros J, Rautureau GJ, Shepherd DA, Pye VE, Muldoon J, Johnson CM, Ashcroft AE, Freund SM, Ferguson N. The hepatitis B virus preS1 domain hijacks host trafficking proteins by motif mimicry. Nat Chem Biol. 2013 Jul 14. doi: 10.1038/nchembio.1294. PMID:23851574 doi:10.1038/nchembio.1294
  1. ↑ Takatsu H, Sakurai M, Shin HW, Murakami K, Nakayama K. Identification and characterization of novel clathrin adaptor-related proteins. J Biol Chem. 1998 Sep 18;273(38):24693-700. PMID:9733768
  2. ↑ Rost M, Mann S, Lambert C, Doring T, Thome N, Prange R. Gamma-adaptin, a novel ubiquitin-interacting adaptor, and Nedd4 ubiquitin ligase control hepatitis B virus maturation. J Biol Chem. 2006 Sep 29;281(39):29297-308. Epub 2006 Jul 25. PMID:16867982 doi:M603517200
  3. ↑ Lambert C, Doring T, Prange R. Hepatitis B virus maturation is sensitive to functional inhibition of ESCRT-III, Vps4, and gamma 2-adaptin. J Virol. 2007 Sep;81(17):9050-60. Epub 2007 Jun 6. PMID:17553870 doi:JVI.00479-07

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OCA

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