2iub
From Proteopedia
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==Overview== | ==Overview== | ||
| - | CorA family members are ubiquitously distributed transporters of divalent | + | CorA family members are ubiquitously distributed transporters of divalent metal cations and are considered to be the primary Mg2+ transporter of Bacteria and Archaea. We have determined a 2.9 angstrom resolution structure of CorA from Thermotoga maritima that reveals a pentameric cone-shaped protein. Two potential regulatory metal binding sites are found in the N-terminal domain that bind both Mg2+ and Co2+. The structure of CorA supports an efflux system involving dehydration and rehydration of divalent metal ions potentially mediated by a ring of conserved aspartate residues at the cytoplasmic entrance and a carbonyl funnel at the periplasmic side of the pore. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Eshaghi, S.]] | [[Category: Eshaghi, S.]] | ||
[[Category: Kohl, A.]] | [[Category: Kohl, A.]] | ||
| - | [[Category: Lesley, S | + | [[Category: Lesley, S A.]] |
| - | [[Category: Molina, D | + | [[Category: Molina, D Martinez.]] |
[[Category: Niegowski, D.]] | [[Category: Niegowski, D.]] | ||
[[Category: Nordlund, P.]] | [[Category: Nordlund, P.]] | ||
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[[Category: membrane protein]] | [[Category: membrane protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:56:04 2008'' |
Revision as of 15:56, 21 February 2008
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CRYSTAL STRUCTURE OF A DIVALENT METAL ION TRANSPORTER CORA AT 2.9 A RESOLUTION.
Overview
CorA family members are ubiquitously distributed transporters of divalent metal cations and are considered to be the primary Mg2+ transporter of Bacteria and Archaea. We have determined a 2.9 angstrom resolution structure of CorA from Thermotoga maritima that reveals a pentameric cone-shaped protein. Two potential regulatory metal binding sites are found in the N-terminal domain that bind both Mg2+ and Co2+. The structure of CorA supports an efflux system involving dehydration and rehydration of divalent metal ions potentially mediated by a ring of conserved aspartate residues at the cytoplasmic entrance and a carbonyl funnel at the periplasmic side of the pore.
About this Structure
2IUB is a Single protein structure of sequence from Thermotoga maritima with and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Crystal structure of a divalent metal ion transporter CorA at 2.9 angstrom resolution., Eshaghi S, Niegowski D, Kohl A, Martinez Molina D, Lesley SA, Nordlund P, Science. 2006 Jul 21;313(5785):354-7. PMID:16857941
Page seeded by OCA on Thu Feb 21 17:56:04 2008
