3vk6
From Proteopedia
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{{STRUCTURE_3vk6| PDB=3vk6 | SCENE= }} | {{STRUCTURE_3vk6| PDB=3vk6 | SCENE= }} | ||
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===Crystal structure of a phosphotyrosine binding domain=== | ===Crystal structure of a phosphotyrosine binding domain=== | ||
| + | {{ABSTRACT_PUBMED_22252131}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/HAKAI_MOUSE HAKAI_MOUSE]] Promotes ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation.<ref>PMID:11836526</ref> <ref>PMID:22252131</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[3vk6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VK6 OCA]. | [[3vk6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VK6 OCA]. | ||
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| + | ==See Also== | ||
| + | *[[Ubiquitin protein ligase|Ubiquitin protein ligase]] | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:022252131</ref><references group="xtra"/><references/> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Mukherjee, M.]] | [[Category: Mukherjee, M.]] | ||
Revision as of 11:17, 24 July 2013
Contents |
Crystal structure of a phosphotyrosine binding domain
Template:ABSTRACT PUBMED 22252131
Function
[HAKAI_MOUSE] Promotes ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation.[1] [2]
About this Structure
3vk6 is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
See Also
Reference
- Mukherjee M, Chow SY, Yusoff P, Seetharaman J, Ng C, Sinniah S, Koh XW, Asgar NF, Li D, Yim D, Jackson RA, Yew J, Qian J, Iyu A, Lim YP, Zhou X, Sze SK, Guy GR, Sivaraman J. Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin. EMBO J. 2012 Jan 17;31(5):1308-19. doi: 10.1038/emboj.2011.496. PMID:22252131 doi:10.1038/emboj.2011.496
- ↑ Fujita Y, Krause G, Scheffner M, Zechner D, Leddy HE, Behrens J, Sommer T, Birchmeier W. Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nat Cell Biol. 2002 Mar;4(3):222-31. PMID:11836526 doi:10.1038/ncb758
- ↑ Mukherjee M, Chow SY, Yusoff P, Seetharaman J, Ng C, Sinniah S, Koh XW, Asgar NF, Li D, Yim D, Jackson RA, Yew J, Qian J, Iyu A, Lim YP, Zhou X, Sze SK, Guy GR, Sivaraman J. Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin. EMBO J. 2012 Jan 17;31(5):1308-19. doi: 10.1038/emboj.2011.496. PMID:22252131 doi:10.1038/emboj.2011.496
