2wbe

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[[Image:2wbe.png|left|200px]]
 
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{{STRUCTURE_2wbe| PDB=2wbe | SCENE= }}
{{STRUCTURE_2wbe| PDB=2wbe | SCENE= }}
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===Kinesin-5-Tubulin Complex with AMPPNP===
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{{ABSTRACT_PUBMED_19285086}}
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===KINESIN-5-TUBULIN COMPLEX WITH AMPPNP===
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==Function==
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[[http://www.uniprot.org/uniprot/TBA1A_PIG TBA1A_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/KL61_DROME KL61_DROME]] Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function. [[http://www.uniprot.org/uniprot/TBB_PIG TBB_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
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{{ABSTRACT_PUBMED_19285086}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:019285086</ref><references group="xtra"/>
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<ref group="xtra">PMID:019285086</ref><references group="xtra"/><references/>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]

Revision as of 11:17, 24 July 2013

Template:STRUCTURE 2wbe

Contents

Kinesin-5-Tubulin Complex with AMPPNP

Template:ABSTRACT PUBMED 19285086

Function

[TBA1A_PIG] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [KL61_DROME] Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function. [TBB_PIG] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

About this Structure

2wbe is a 3 chain structure with sequence from Bos taurus and Drosophila melanogaster. Full crystallographic information is available from OCA.

See Also

Reference

  • Bodey AJ, Kikkawa M, Moores CA. 9-Angstrom structure of a microtubule-bound mitotic motor. J Mol Biol. 2009 May 1;388(2):218-24. Epub 2009 Mar 10. PMID:19285086 doi:10.1016/j.jmb.2009.03.008

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OCA

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