2iuh

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(New page: 200px<br /> <applet load="2iuh" size="450" color="white" frame="true" align="right" spinBox="true" caption="2iuh, resolution 2.00&Aring;" /> '''CRYSTAL STRUCTURE O...)
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'''CRYSTAL STRUCTURE OF THE PI3-KINASE P85 N-TERMINAL SH2 DOMAIN IN COMPLEX WITH C-KIT PHOSPHOTYROSYL PEPTIDE'''<br />
'''CRYSTAL STRUCTURE OF THE PI3-KINASE P85 N-TERMINAL SH2 DOMAIN IN COMPLEX WITH C-KIT PHOSPHOTYROSYL PEPTIDE'''<br />
==Overview==
==Overview==
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Crystal structures of the amino-terminal SH2 domain of the p85alpha, subunit of phosphatidylinositol (PI) 3-kinase, alone and in complex with, phosphopeptides bearing pTyr-Met/Val-Xaa-Met motifs, show that, phosphopeptides bind in the two-pronged manner seen in high-affinity Lck, and Src SH2 complexes, with conserved interactions between the domain and, the peptide segment from phosphotyrosine to Met+3. Peptide binding, requires the rearrangement of a tyrosyl side chain in the BG loop to, create the hydrophobic Met+3 binding pocket. The structures suggest a, mechanism for the biological specificity exhibited by PI 3-kinase in its, interactions with phosphoprotein partners.
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Crystal structures of the amino-terminal SH2 domain of the p85alpha subunit of phosphatidylinositol (PI) 3-kinase, alone and in complex with phosphopeptides bearing pTyr-Met/Val-Xaa-Met motifs, show that phosphopeptides bind in the two-pronged manner seen in high-affinity Lck and Src SH2 complexes, with conserved interactions between the domain and the peptide segment from phosphotyrosine to Met+3. Peptide binding requires the rearrangement of a tyrosyl side chain in the BG loop to create the hydrophobic Met+3 binding pocket. The structures suggest a mechanism for the biological specificity exhibited by PI 3-kinase in its interactions with phosphoprotein partners.
==About this Structure==
==About this Structure==
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2IUH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2IUH OCA].
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2IUH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUH OCA].
==Reference==
==Reference==
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Eck, M.J.]]
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[[Category: Eck, M J.]]
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[[Category: Harrison, S.C.]]
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[[Category: Harrison, S C.]]
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[[Category: Nolte, R.T.]]
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[[Category: Nolte, R T.]]
[[Category: Schlessinger, J.]]
[[Category: Schlessinger, J.]]
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[[Category: Shoelson, S.E.]]
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[[Category: Shoelson, S E.]]
[[Category: disease mutation]]
[[Category: disease mutation]]
[[Category: p85]]
[[Category: p85]]
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[[Category: ubl conjugation]]
[[Category: ubl conjugation]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 22:48:15 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:56:10 2008''

Revision as of 15:56, 21 February 2008

Image:2iuh.gif

2iuh, resolution 2.00Å

Drag the structure with the mouse to rotate

CRYSTAL STRUCTURE OF THE PI3-KINASE P85 N-TERMINAL SH2 DOMAIN IN COMPLEX WITH C-KIT PHOSPHOTYROSYL PEPTIDE

Overview

Crystal structures of the amino-terminal SH2 domain of the p85alpha subunit of phosphatidylinositol (PI) 3-kinase, alone and in complex with phosphopeptides bearing pTyr-Met/Val-Xaa-Met motifs, show that phosphopeptides bind in the two-pronged manner seen in high-affinity Lck and Src SH2 complexes, with conserved interactions between the domain and the peptide segment from phosphotyrosine to Met+3. Peptide binding requires the rearrangement of a tyrosyl side chain in the BG loop to create the hydrophobic Met+3 binding pocket. The structures suggest a mechanism for the biological specificity exhibited by PI 3-kinase in its interactions with phosphoprotein partners.

About this Structure

2IUH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes., Nolte RT, Eck MJ, Schlessinger J, Shoelson SE, Harrison SC, Nat Struct Biol. 1996 Apr;3(4):364-74. PMID:8599763

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