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4j8s

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{{STRUCTURE_4j8s| PDB=4j8s | SCENE= }}
{{STRUCTURE_4j8s| PDB=4j8s | SCENE= }}
===Crystal structure of human CNOT1 MIF4G domain in complex with a TTP peptide===
===Crystal structure of human CNOT1 MIF4G domain in complex with a TTP peptide===
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{{ABSTRACT_PUBMED_23644599}}
==Function==
==Function==
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==Reference==
==Reference==
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<references group="xtra"/><references/>
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<ref group="xtra">PMID:023644599</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Blackshear, P J.]]
[[Category: Blackshear, P J.]]

Revision as of 11:43, 24 July 2013

Template:STRUCTURE 4j8s

Contents

Crystal structure of human CNOT1 MIF4G domain in complex with a TTP peptide

Template:ABSTRACT PUBMED 23644599

Function

[CNOT1_HUMAN] Belongs to the CCR4-NOT complex that functions as general transcription regulation complex. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors.[1] [2] [TTP_HUMAN] mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).[3]

About this Structure

4j8s is a 2 chain structure with sequence from [1] and Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Fabian MR, Frank F, Rouya C, Siddiqui N, Lai WS, Karetnikov A, Blackshear PJ, Nagar B, Sonenberg N. Structural basis for the recruitment of the human CCR4-NOT deadenylase complex by tristetraprolin. Nat Struct Mol Biol. 2013 Jun;20(6):735-9. doi: 10.1038/nsmb.2572. Epub 2013 May , 5. PMID:23644599 doi:10.1038/nsmb.2572
  1. ↑ Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. Nucleic Acids Res. 2000 Feb 1;28(3):809-17. PMID:10637334
  2. ↑ Winkler GS, Mulder KW, Bardwell VJ, Kalkhoven E, Timmers HT. Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription. EMBO J. 2006 Jul 12;25(13):3089-99. Epub 2006 Jun 15. PMID:16778766 doi:7601194
  3. ↑ Stoecklin G, Stubbs T, Kedersha N, Wax S, Rigby WF, Blackwell TK, Anderson P. MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. EMBO J. 2004 Mar 24;23(6):1313-24. Epub 2004 Mar 11. PMID:15014438 doi:10.1038/sj.emboj.7600163

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