2g6q

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m (Protected "2g6q" [edit=sysop:move=sysop])
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[[Image:2g6q.png|left|200px]]
 
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{{STRUCTURE_2g6q| PDB=2g6q | SCENE= }}
{{STRUCTURE_2g6q| PDB=2g6q | SCENE= }}
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===Crystal structure of ING2 PHD finger in complex with H3K4Me3 peptide===
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{{ABSTRACT_PUBMED_16728977}}
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===Crystal structure of ING2 PHD domain in complex with H3K4Me3 peptide===
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==Function==
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[[http://www.uniprot.org/uniprot/ING2_MOUSE ING2_MOUSE]] Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs) (By similarity).
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{{ABSTRACT_PUBMED_16728977}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:016728977</ref><references group="xtra"/>
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<ref group="xtra">PMID:016728977</ref><references group="xtra"/><references/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Kutateladze, T G.]]
[[Category: Kutateladze, T G.]]
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[[Category: Apoptosis]]
[[Category: Apoptosis]]
[[Category: Gene regulation]]
[[Category: Gene regulation]]
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[[Category: Phd finger]]
[[Category: Protein-peptide complex]]
[[Category: Protein-peptide complex]]

Revision as of 11:47, 24 July 2013

Template:STRUCTURE 2g6q

Contents

Crystal structure of ING2 PHD finger in complex with H3K4Me3 peptide

Template:ABSTRACT PUBMED 16728977

Function

[ING2_MOUSE] Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs) (By similarity).

About this Structure

2g6q is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Pena PV, Davrazou F, Shi X, Walter KL, Verkhusha VV, Gozani O, Zhao R, Kutateladze TG. Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2. Nature. 2006 Jul 6;442(7098):100-3. Epub 2006 May 21. PMID:16728977 doi:10.1038/nature04814

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OCA

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