4kbb
From Proteopedia
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{{STRUCTURE_4kbb| PDB=4kbb | SCENE= }} | {{STRUCTURE_4kbb| PDB=4kbb | SCENE= }} | ||
===Structure of Botulinum neurotoxin B binding domain in complex with both synaptotagmin II and GD1a=== | ===Structure of Botulinum neurotoxin B binding domain in complex with both synaptotagmin II and GD1a=== | ||
| + | {{ABSTRACT_PUBMED_23807078}} | ||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[4kbb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KBB OCA]. | [[4kbb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KBB OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023807078</ref><references group="xtra"/><references/> | ||
[[Category: Bontoxilysin]] | [[Category: Bontoxilysin]] | ||
[[Category: Clostridium botulinum]] | [[Category: Clostridium botulinum]] | ||
Revision as of 11:49, 24 July 2013
Contents |
Structure of Botulinum neurotoxin B binding domain in complex with both synaptotagmin II and GD1a
Template:ABSTRACT PUBMED 23807078
Function
[BXB_CLOBO] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2. [SYT2_MOUSE] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
About this Structure
4kbb is a 4 chain structure with sequence from Clostridium botulinum and Mus musculus. Full crystallographic information is available from OCA.
Reference
- Berntsson RP, Peng L, Dong M, Stenmark P. Structure of dual receptor binding to botulinum neurotoxin B. Nat Commun. 2013 Jun 28;4:2058. doi: 10.1038/ncomms3058. PMID:23807078 doi:10.1038/ncomms3058
