2ixq

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(New page: 200px<br /><applet load="2ixq" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ixq" /> '''THE SOLUTION STRUCTURE OF THE INVASIVE TIP C...)
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[[Image:2ixq.gif|left|200px]]<br /><applet load="2ixq" size="350" color="white" frame="true" align="right" spinBox="true"
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'''THE SOLUTION STRUCTURE OF THE INVASIVE TIP COMPLEX FROM AFA-DR FIBRILS'''<br />
'''THE SOLUTION STRUCTURE OF THE INVASIVE TIP COMPLEX FROM AFA-DR FIBRILS'''<br />
==Overview==
==Overview==
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Afa/Dr family of adhesins are produced by pathogenic Escherichia coli, strains that are especially prevalent in chronic diarrhoeal and recurrent, urinary tract infections. Most notably, they are found in up to 50% of, cystitis cases in children and 30% of pyelonephritis in pregnant women., Afa/Dr adhesins are capped surface fibrils that mediate recognition of the, host and subsequent bacterial internalization. Using the newly solved, three-dimensional structure of the minimal invasive complex (AfaDE), combined with biochemical and cellular assays, we reveal the architecture, of the fibrillar cap and identify a novel mode of synergistic integrin, recognition.
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Afa/Dr family of adhesins are produced by pathogenic Escherichia coli strains that are especially prevalent in chronic diarrhoeal and recurrent urinary tract infections. Most notably, they are found in up to 50% of cystitis cases in children and 30% of pyelonephritis in pregnant women. Afa/Dr adhesins are capped surface fibrils that mediate recognition of the host and subsequent bacterial internalization. Using the newly solved three-dimensional structure of the minimal invasive complex (AfaDE) combined with biochemical and cellular assays, we reveal the architecture of the fibrillar cap and identify a novel mode of synergistic integrin recognition.
==About this Structure==
==About this Structure==
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2IXQ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2IXQ OCA].
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2IXQ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXQ OCA].
==Reference==
==Reference==
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[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Altroff, H.]]
[[Category: Altroff, H.]]
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[[Category: Anderson, K.L.]]
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[[Category: Anderson, K L.]]
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[[Category: Bouguenec, C.Le.]]
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[[Category: Bouguenec, C Le.]]
[[Category: Cota, E.]]
[[Category: Cota, E.]]
[[Category: Guignot, J.]]
[[Category: Guignot, J.]]
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[[Category: Mardon, H.]]
[[Category: Mardon, H.]]
[[Category: Matthews, S.]]
[[Category: Matthews, S.]]
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[[Category: Merle, L.Du.]]
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[[Category: Merle, L Du.]]
[[Category: Servin, A.]]
[[Category: Servin, A.]]
[[Category: Simpson, P.]]
[[Category: Simpson, P.]]
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[[Category: upec]]
[[Category: upec]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 12:27:44 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:57:07 2008''

Revision as of 15:57, 21 February 2008

Image:2ixq.gif

2ixq

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THE SOLUTION STRUCTURE OF THE INVASIVE TIP COMPLEX FROM AFA-DR FIBRILS

Overview

Afa/Dr family of adhesins are produced by pathogenic Escherichia coli strains that are especially prevalent in chronic diarrhoeal and recurrent urinary tract infections. Most notably, they are found in up to 50% of cystitis cases in children and 30% of pyelonephritis in pregnant women. Afa/Dr adhesins are capped surface fibrils that mediate recognition of the host and subsequent bacterial internalization. Using the newly solved three-dimensional structure of the minimal invasive complex (AfaDE) combined with biochemical and cellular assays, we reveal the architecture of the fibrillar cap and identify a novel mode of synergistic integrin recognition.

About this Structure

2IXQ is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

The solution structure of the invasive tip complex from Afa/Dr fibrils., Cota E, Jones C, Simpson P, Altroff H, Anderson KL, du Merle L, Guignot J, Servin A, Le Bouguenec C, Mardon H, Matthews S, Mol Microbiol. 2006 Oct;62(2):356-66. Epub 2006 Sep 8. PMID:16965519

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