4kpb

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m (Protected "4kpb" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4kpb| PDB=4kpb | SCENE= }}
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===Crystal structure of cytochrome P450 BM-3 R47E mutant===
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{{ABSTRACT_PUBMED_23829560}}
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The entry 4kpb is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/CPXB_BACME CPXB_BACME]] Functions as a fatty acid monooxygenase. Catalyzes hydroxylation of medium and long-chain fatty acids at omega-1, omega-2 and omega-3 positions, with optimum chain lengths of 12-16 carbons (lauric, myristic, and palmitic acids). The reductase domain is required for electron transfer from NADP to cytochrome P450.
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Authors: Sadre-Bazzaz, K., Catalano, J., McDermott, A.E., Tong, L.
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==About this Structure==
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[[4kpb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_megaterium Bacillus megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KPB OCA].
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Description: Crystal structure of cytochrome P450 BM-3 R47E mutant
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==Reference==
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<ref group="xtra">PMID:023829560</ref><references group="xtra"/><references/>
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[[Category: Bacillus megaterium]]
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[[Category: Unspecific monooxygenase]]
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[[Category: Catalano, J.]]
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[[Category: McDermott, A E.]]
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[[Category: Sadre-Bazzaz, K.]]
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[[Category: Tong, L.]]
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[[Category: Heme-dependent stereospecific oxidation of substrate]]
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[[Category: Oxidoreductase]]

Revision as of 12:58, 24 July 2013

Template:STRUCTURE 4kpb

Contents

Crystal structure of cytochrome P450 BM-3 R47E mutant

Template:ABSTRACT PUBMED 23829560

Function

[CPXB_BACME] Functions as a fatty acid monooxygenase. Catalyzes hydroxylation of medium and long-chain fatty acids at omega-1, omega-2 and omega-3 positions, with optimum chain lengths of 12-16 carbons (lauric, myristic, and palmitic acids). The reductase domain is required for electron transfer from NADP to cytochrome P450.

About this Structure

4kpb is a 2 chain structure with sequence from Bacillus megaterium. Full crystallographic information is available from OCA.

Reference

  • Catalano J, Sadre-Bazzaz K, Amodeo GA, Tong L, McDermott AE. Structural Evidence: A Single Charged Residue Affects Substrate Binding in Cytochrome P450 BM-3. Biochemistry. 2013 Jul 6. PMID:23829560 doi:10.1021/bi4000645

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OCA

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