4bru

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'''Unreleased structure'''
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{{STRUCTURE_4bru| PDB=4bru | SCENE= }}
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===Crystal structure of the yeast Dhh1-Edc3 complex===
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{{ABSTRACT_PUBMED_23851565}}
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The entry 4bru is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/DHH1_YEAST DHH1_YEAST]] ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping by activating the decapping enzyme DCP1. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export. Required for sporulation.<ref>PMID:9504907</ref> <ref>PMID:11780629</ref> <ref>PMID:12032091</ref> <ref>PMID:11696541</ref> <ref>PMID:12930949</ref> <ref>PMID:12730603</ref> <ref>PMID:15166134</ref> <ref>PMID:15703442</ref> <ref>PMID:15706350</ref> [[http://www.uniprot.org/uniprot/EDC3_YEAST EDC3_YEAST]] Stimulates decapping of both stable and unstable mRNA during mRNA decay. Does not affect nonsense-mediated mRNA decay. Required for normal P-body assembly.<ref>PMID:18678652</ref> <ref>PMID:15020463</ref>
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Authors: Sharif, H., Ozgur, S., Sharma, K., Basquin, C., Urlaub, H., Conti, E.
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==About this Structure==
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[[4bru]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BRU OCA].
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Description: Crystal structure of the yeast Dhh1-Edc3 complex
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==Reference==
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<ref group="xtra">PMID:023851565</ref><references group="xtra"/><references/>
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[[Category: RNA helicase]]
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[[Category: Saccharomyces cerevisiae s288c]]
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[[Category: Basquin, C.]]
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[[Category: Conti, E.]]
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[[Category: Ozgur, S.]]
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[[Category: Sharif, H.]]
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[[Category: Sharma, K.]]
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[[Category: Urlaub, H.]]
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[[Category: Dead-box]]
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[[Category: Decapping]]
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[[Category: Hydrolase]]
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[[Category: Mrnp remodel p-body]]
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[[Category: Translational repression]]

Revision as of 12:59, 24 July 2013

Template:STRUCTURE 4bru

Contents

Crystal structure of the yeast Dhh1-Edc3 complex

Template:ABSTRACT PUBMED 23851565

Function

[DHH1_YEAST] ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping by activating the decapping enzyme DCP1. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export. Required for sporulation.[1] [2] [3] [4] [5] [6] [7] [8] [9] [EDC3_YEAST] Stimulates decapping of both stable and unstable mRNA during mRNA decay. Does not affect nonsense-mediated mRNA decay. Required for normal P-body assembly.[10] [11]

About this Structure

4bru is a 2 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.

Reference

  • Sharif H, Ozgur S, Sharma K, Basquin C, Urlaub H, Conti E. Structural analysis of the yeast Dhh1-Pat1 complex reveals how Dhh1 engages Pat1, Edc3 and RNA in mutually exclusive interactions. Nucleic Acids Res. 2013 Jul 12. PMID:23851565 doi:10.1093/nar/gkt600
  1. ↑ Hata H, Mitsui H, Liu H, Bai Y, Denis CL, Shimizu Y, Sakai A. Dhh1p, a putative RNA helicase, associates with the general transcription factors Pop2p and Ccr4p from Saccharomyces cerevisiae. Genetics. 1998 Feb;148(2):571-9. PMID:9504907
  2. ↑ Coller JM, Tucker M, Sheth U, Valencia-Sanchez MA, Parker R. The DEAD box helicase, Dhh1p, functions in mRNA decapping and interacts with both the decapping and deadenylase complexes. RNA. 2001 Dec;7(12):1717-27. PMID:11780629
  3. ↑ Fischer N, Weis K. The DEAD box protein Dhh1 stimulates the decapping enzyme Dcp1. EMBO J. 2002 Jun 3;21(11):2788-97. PMID:12032091 doi:10.1093/emboj/21.11.2788
  4. ↑ Maillet L, Collart MA. Interaction between Not1p, a component of the Ccr4-not complex, a global regulator of transcription, and Dhh1p, a putative RNA helicase. J Biol Chem. 2002 Jan 25;277(4):2835-42. Epub 2001 Nov 5. PMID:11696541 doi:10.1074/jbc.M107979200
  5. ↑ Tseng-Rogenski SS, Chong JL, Thomas CB, Enomoto S, Berman J, Chang TH. Functional conservation of Dhh1p, a cytoplasmic DExD/H-box protein present in large complexes. Nucleic Acids Res. 2003 Sep 1;31(17):4995-5002. PMID:12930949
  6. ↑ Sheth U, Parker R. Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science. 2003 May 2;300(5620):805-8. PMID:12730603 doi:10.1126/science.1082320
  7. ↑ Bergkessel M, Reese JC. An essential role for the Saccharomyces cerevisiae DEAD-box helicase DHH1 in G1/S DNA-damage checkpoint recovery. Genetics. 2004 May;167(1):21-33. PMID:15166134
  8. ↑ Teixeira D, Sheth U, Valencia-Sanchez MA, Brengues M, Parker R. Processing bodies require RNA for assembly and contain nontranslating mRNAs. RNA. 2005 Apr;11(4):371-82. Epub 2005 Feb 9. PMID:15703442 doi:10.1261/rna.7258505
  9. ↑ Muhlrad D, Parker R. The yeast EDC1 mRNA undergoes deadenylation-independent decapping stimulated by Not2p, Not4p, and Not5p. EMBO J. 2005 Mar 9;24(5):1033-45. Epub 2005 Feb 10. PMID:15706350 doi:10.1038/sj.emboj.7600560
  10. ↑ Ling SH, Decker CJ, Walsh MA, She M, Parker R, Song H. Crystal structure of human Edc3 and its functional implications. Mol Cell Biol. 2008 Oct;28(19):5965-76. Epub 2008 Aug 4. PMID:18678652 doi:10.1128/MCB.00761-08
  11. ↑ Kshirsagar M, Parker R. Identification of Edc3p as an enhancer of mRNA decapping in Saccharomyces cerevisiae. Genetics. 2004 Feb;166(2):729-39. PMID:15020463

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