4jsc

(Difference between revisions)

Revision as of 13:00, 24 July 2013

[MDM2_XENLA] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity).

4jsc is a 2 chain structure with sequence from Xenopus laevis. Full crystallographic information is available from OCA.

Ding Q, Zhang Z, Liu JJ, Jiang N, Zhang J, Ross TM, Chu XJ, Bartkovitz D, Podlaski F, Janson C, Tovar C, Filipovic ZM, Higgins B, Glenn K, Packman K, Vassilev LT, Graves B. Discovery of RG7388, a Potent and Selective p53-MDM2 Inhibitor in Clinical Development. J Med Chem. 2013 Jul 16. PMID:23808545 doi:10.1021/jm400487c

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-'''Unreleased structure'''
+{{STRUCTURE_4jsc|  PDB=4jsc  |  SCENE=  }}
+===The 2.5A crystal structure of humanized Xenopus MDM2 with RO5316533 - a pyrrolidine MDM2 inhibitor===
+{{ABSTRACT_PUBMED_23808545}}
-The entry 4jsc is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/MDM2_XENLA MDM2_XENLA]] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity).
-Authors: Janson, C.A., Lukacs, C., Graves, B.
+==About this Structure==
+[[4jsc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JSC OCA].
-Description: The 2.5A crystal structure of humanized Xenopus MDM2 with RO5316533 -a pyrrolidine MDM2 inhibitor
+==Reference==
+<ref group="xtra">PMID:023808545</ref><references group="xtra"/><references/>
+[[Category: Xenopus laevis]]
+[[Category: Graves, B.]]
+[[Category: Janson, C A.]]
+[[Category: Lukacs, C.]]
+[[Category: E3 ubiquitin ligase]]
+[[Category: Ligase-antagonist complex]]
+[[Category: Ligase-ligase inhibitor complex]]
+[[Category: Nucleus]]
+[[Category: P53]]
+[[Category: Pyrrolidine]]