3wcy

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'''Unreleased structure'''
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{{STRUCTURE_3wcy| PDB=3wcy | SCENE= }}
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===Murine Ifnar1 in complex with interferon-beta===
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The entry 3wcy is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/INAR1_MOUSE INAR1_MOUSE]] Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. [[http://www.uniprot.org/uniprot/IFNB_MOUSE IFNB_MOUSE]] Has antiviral, antibacterial and anticancer activities.
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Authors: Vivian, J.P., de Weerd, N.A., Hertzog, P.J., Rossjohn, J.
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==About this Structure==
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[[3wcy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WCY OCA].
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Description: Protein Complex
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[[Category: Mus musculus]]
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[[Category: Hertzog, P J.]]
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[[Category: Rossjohn, J.]]
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[[Category: Vivian, J P.]]
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[[Category: Weerd, N A.de.]]
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[[Category: Cytokine receptor]]
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[[Category: Cytokine receptor-cytokine complex]]
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[[Category: Fibronectin type iii]]
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[[Category: Helical cytokine]]
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[[Category: Interferon]]

Revision as of 13:00, 24 July 2013

Template:STRUCTURE 3wcy

Murine Ifnar1 in complex with interferon-beta

Function

[INAR1_MOUSE] Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. [IFNB_MOUSE] Has antiviral, antibacterial and anticancer activities.

About this Structure

3wcy is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

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OCA

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