4lc2

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m (Protected "4lc2" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4lc2| PDB=4lc2 | SCENE= }}
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===Crystal structure of the bromodomain of human BRPF1B===
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The entry 4lc2 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref>
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Authors: Tallant, C., Nunez-Alonso, G., Savitsky, P., Picaud, S., Filippakopoulos, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
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==About this Structure==
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[[4lc2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LC2 OCA].
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Description: Crystal structure of the bromodomain of human BRPF1B
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Bountra, C.]]
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[[Category: Delft, F von.]]
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[[Category: Edwards, A M.]]
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[[Category: Filippakopoulos, P.]]
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[[Category: Knapp, S.]]
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[[Category: Nunez-Alonso, G.]]
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[[Category: Picaud, S.]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Savitsky, P.]]
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[[Category: Tallant, C.]]
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[[Category: Bromodomain and phd finger-containing protein 1]]
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[[Category: Dna binding protein]]
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[[Category: Protein br140]]
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[[Category: Sgc]]
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[[Category: Structural genomics consortium]]

Revision as of 13:14, 24 July 2013

Template:STRUCTURE 4lc2

Contents

Crystal structure of the bromodomain of human BRPF1B

Function

[BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.[1] [2]

About this Structure

4lc2 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS, Tan S, Yang XJ, Cote J. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell. 2006 Jan 6;21(1):51-64. PMID:16387653 doi:10.1016/j.molcel.2005.12.007
  2. ↑ Ullah M, Pelletier N, Xiao L, Zhao SP, Wang K, Degerny C, Tahmasebi S, Cayrou C, Doyon Y, Goh SL, Champagne N, Cote J, Yang XJ. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. Mol Cell Biol. 2008 Nov;28(22):6828-43. doi: 10.1128/MCB.01297-08. Epub 2008 Sep , 15. PMID:18794358 doi:10.1128/MCB.01297-08

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OCA

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