2j01
From Proteopedia
(New page: 200px<br /><applet load="2j01" size="450" color="white" frame="true" align="right" spinBox="true" caption="2j01, resolution 2.8Å" /> '''STRUCTURE OF THE THER...) |
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| - | [[Image:2j01.gif|left|200px]]<br /><applet load="2j01" size=" | + | [[Image:2j01.gif|left|200px]]<br /><applet load="2j01" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2j01, resolution 2.8Å" /> | caption="2j01, resolution 2.8Å" /> | ||
'''STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME COMPLEXED WITH MRNA, TRNA AND PAROMOMYCIN (PART 2 OF 4). THIS FILE CONTAINS THE 50S SUBUNIT FROM MOLECULE I.'''<br /> | '''STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME COMPLEXED WITH MRNA, TRNA AND PAROMOMYCIN (PART 2 OF 4). THIS FILE CONTAINS THE 50S SUBUNIT FROM MOLECULE I.'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structure of the bacterial 70S ribosome refined to 2.8 | + | The crystal structure of the bacterial 70S ribosome refined to 2.8 angstrom resolution reveals atomic details of its interactions with messenger RNA (mRNA) and transfer RNA (tRNA). A metal ion stabilizes a kink in the mRNA that demarcates the boundary between A and P sites, which is potentially important to prevent slippage of mRNA. Metal ions also stabilize the intersubunit interface. The interactions of E-site tRNA with the 50S subunit have both similarities and differences compared to those in the archaeal ribosome. The structure also rationalizes much biochemical and genetic data on translation. |
==About this Structure== | ==About this Structure== | ||
| - | 2J01 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http:// | + | 2J01 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J01 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Thermus thermophilus]] | [[Category: Thermus thermophilus]] | ||
| - | [[Category: Dunham, C | + | [[Category: Dunham, C M.]] |
| - | [[Category: Kelley, A | + | [[Category: Kelley, A C.]] |
| - | [[Category: Murphy, F | + | [[Category: Murphy, F V.]] |
[[Category: Petry, S.]] | [[Category: Petry, S.]] | ||
[[Category: Ramakrishnan, V.]] | [[Category: Ramakrishnan, V.]] | ||
[[Category: Selmer, M.]] | [[Category: Selmer, M.]] | ||
| - | [[Category: Weir, J | + | [[Category: Weir, J R.]] |
[[Category: Weixlbaumer, A.]] | [[Category: Weixlbaumer, A.]] | ||
[[Category: mrna]] | [[Category: mrna]] | ||
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[[Category: trna]] | [[Category: trna]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:57:49 2008'' |
Revision as of 15:57, 21 February 2008
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STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME COMPLEXED WITH MRNA, TRNA AND PAROMOMYCIN (PART 2 OF 4). THIS FILE CONTAINS THE 50S SUBUNIT FROM MOLECULE I.
Overview
The crystal structure of the bacterial 70S ribosome refined to 2.8 angstrom resolution reveals atomic details of its interactions with messenger RNA (mRNA) and transfer RNA (tRNA). A metal ion stabilizes a kink in the mRNA that demarcates the boundary between A and P sites, which is potentially important to prevent slippage of mRNA. Metal ions also stabilize the intersubunit interface. The interactions of E-site tRNA with the 50S subunit have both similarities and differences compared to those in the archaeal ribosome. The structure also rationalizes much biochemical and genetic data on translation.
About this Structure
2J01 is a Protein complex structure of sequences from Thermus thermophilus. Full crystallographic information is available from OCA.
Reference
Structure of the 70S ribosome complexed with mRNA and tRNA., Selmer M, Dunham CM, Murphy FV 4th, Weixlbaumer A, Petry S, Kelley AC, Weir JR, Ramakrishnan V, Science. 2006 Sep 29;313(5795):1935-42. Epub 2006 Sep 7. PMID:16959973
Page seeded by OCA on Thu Feb 21 17:57:49 2008
