2lvz

From Proteopedia

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m (Protected "2lvz" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_2lvz| PDB=2lvz | SCENE= }}
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===Solution structure of a Eosinophil Cationic Protein-trisaccharide heparin mimetic complex===
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{{ABSTRACT_PUBMED_23025322}}
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The entry 2lvz is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/ECP_HUMAN ECP_HUMAN]] Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.<ref>PMID:2501794</ref> <ref>PMID:19450231</ref>
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Authors: Garcia Mayoral, M., Canales, A., Diaz, D., Lopez Prados, J., Moussaoui, M., de Paz, J., Angulo, J., Nieto, P., Jimenez Barbero, J., Boix, E., Bruix, M.
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==About this Structure==
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[[2lvz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LVZ OCA].
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Description: Solution structure of a Eosinophil Cationic Protein-trisaccharide heparin mimetic complex
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==Reference==
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<ref group="xtra">PMID:023025322</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Angulo, J.]]
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[[Category: Barbero, J Jimenez.]]
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[[Category: Boix, E.]]
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[[Category: Bruix, M.]]
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[[Category: Canales, A.]]
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[[Category: Diaz, D.]]
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[[Category: Mayoral, M Garcia.]]
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[[Category: Moussaoui, M.]]
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[[Category: Nieto, P.]]
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[[Category: Paz, J de.]]
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[[Category: Prados, J Lopez.]]
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[[Category: Heparin]]
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[[Category: Hydrolase]]
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[[Category: Molecular recognition]]

Revision as of 05:11, 1 August 2013

Template:STRUCTURE 2lvz

Contents

Solution structure of a Eosinophil Cationic Protein-trisaccharide heparin mimetic complex

Template:ABSTRACT PUBMED 23025322

Function

[ECP_HUMAN] Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.[1] [2]

About this Structure

2lvz is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Garcia-Mayoral MF, Canales A, Diaz D, Lopez-Prados J, Moussaoui M, de Paz JL, Angulo J, Nieto PM, Jimenez-Barbero J, Boix E, Bruix M. Insights into the glycosaminoglycan-mediated cytotoxic mechanism of eosinophil cationic protein revealed by NMR. ACS Chem Biol. 2013 Jan 18;8(1):144-51. doi: 10.1021/cb300386v. Epub 2012 Oct 9. PMID:23025322 doi:10.1021/cb300386v
  1. ↑ Gabay JE, Scott RW, Campanelli D, Griffith J, Wilde C, Marra MN, Seeger M, Nathan CF. Antibiotic proteins of human polymorphonuclear leukocytes. Proc Natl Acad Sci U S A. 1989 Jul;86(14):5610-4. PMID:2501794
  2. ↑ Torrent M, de la Torre BG, Nogues VM, Andreu D, Boix E. Bactericidal and membrane disruption activities of the eosinophil cationic protein are largely retained in an N-terminal fragment. Biochem J. 2009 Jul 15;421(3):425-34. doi: 10.1042/BJ20082330. PMID:19450231 doi:10.1042/BJ20082330

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