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2ypb

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'''Unreleased structure'''
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{{STRUCTURE_2ypb| PDB=2ypb | SCENE= }}
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===Structure of the SCL:E47 complex bound to DNA===
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{{ABSTRACT_PUBMED_23831025}}
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The entry 2ypb is ON HOLD until Paper Publication
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==Disease==
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[[http://www.uniprot.org/uniprot/TAL1_HUMAN TAL1_HUMAN]] Precursor T-cell acute lymphoblastic leukemia. A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes. [[http://www.uniprot.org/uniprot/TFE2_HUMAN TFE2_HUMAN]] Precursor B-cell acute lymphoblastic leukemia. Chromosomal aberrations involving TCF3 are cause of forms of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(1;19)(q23;p13.3) with PBX1. TCF3-PBX1 transforms cells by constitutively activating transcription of genes regulated by PBX1 or by other members of the PBX protein family. Translocation t(17;19)(q22;p13.3) with HLF. Inversion inv(19)(p13;q13) with TFPT.
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Authors: El Omari, K., Hoosdally, S.J., Tuladhar, K., Karia, D., Ponsele, E., Platonova, O., Vyas, P., Patient, R., Porcher, C., Mancini, E.J.
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==Function==
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[[http://www.uniprot.org/uniprot/TAL1_HUMAN TAL1_HUMAN]] Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).<ref>PMID:1396592</ref> [[http://www.uniprot.org/uniprot/TFE2_HUMAN TFE2_HUMAN]] Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.
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Description:
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==About this Structure==
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[[2ypb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPB OCA].
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==Reference==
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<ref group="xtra">PMID:023831025</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Hoosdally, S J.]]
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[[Category: Karia, D.]]
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[[Category: Mancini, E J.]]
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[[Category: Omari, K El.]]
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[[Category: Patient, R.]]
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[[Category: Platonova, O.]]
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[[Category: Ponsele, E.]]
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[[Category: Porcher, C.]]
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[[Category: Tuladhar, K.]]
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[[Category: Vyas, P.]]
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[[Category: Hematopoiesis]]
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[[Category: Immune system]]
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[[Category: Leukemia]]

Revision as of 05:11, 1 August 2013

Template:STRUCTURE 2ypb

Contents

Structure of the SCL:E47 complex bound to DNA

Template:ABSTRACT PUBMED 23831025

Disease

[TAL1_HUMAN] Precursor T-cell acute lymphoblastic leukemia. A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes. [TFE2_HUMAN] Precursor B-cell acute lymphoblastic leukemia. Chromosomal aberrations involving TCF3 are cause of forms of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(1;19)(q23;p13.3) with PBX1. TCF3-PBX1 transforms cells by constitutively activating transcription of genes regulated by PBX1 or by other members of the PBX protein family. Translocation t(17;19)(q22;p13.3) with HLF. Inversion inv(19)(p13;q13) with TFPT.

Function

[TAL1_HUMAN] Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).[1] [TFE2_HUMAN] Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.

About this Structure

2ypb is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • El Omari K, Hoosdally SJ, Tuladhar K, Karia D, Hall-Ponsele E, Platonova O, Vyas P, Patient R, Porcher C, Mancini EJ. Structural Basis for LMO2-Driven Recruitment of the SCL:E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional Targets. Cell Rep. 2013 Jul 11;4(1):135-47. doi: 10.1016/j.celrep.2013.06.008. Epub 2013, Jul 3. PMID:23831025 doi:10.1016/j.celrep.2013.06.008
  1. ↑ Aplan PD, Nakahara K, Orkin SH, Kirsch IR. The SCL gene product: a positive regulator of erythroid differentiation. EMBO J. 1992 Nov;11(11):4073-81. PMID:1396592

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