4b1w

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m (Protected "4b1w" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4b1w| PDB=4b1w | SCENE= }}
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===Structure of the Phactr1 RPEL-2 domain bound to actin===
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The entry 4b1w is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. [[http://www.uniprot.org/uniprot/PHAR1_MOUSE PHAR1_MOUSE]] Binds actin monomers (G actin) and plays a role in the reorganization of the actin cytoskeleton and in formation of actin stress fibers. Plays a role in the formation of tubules by endothelial cells. Regulates PPP1CA activity. Required for normal cell survival (By similarity). Plays a role in cell motility.<ref>PMID:22976292</ref> <ref>PMID:23041370</ref>
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Authors: Mouilleron, S., Wiezlak, M., O'Reilly, N., Treisman, R., McDonald, N.Q.
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==About this Structure==
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[[4b1w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B1W OCA].
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Description: Structure of the Phactr1 RPEL-2 domain bound to actin
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Oryctolagus cuniculus]]
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[[Category: McDonald, N Q.]]
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[[Category: Mouilleron, S.]]
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[[Category: Reilly, N O.]]
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[[Category: Treisman, R.]]
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[[Category: Wiezlak, M.]]
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[[Category: Atp-binding]]
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[[Category: Cytoskeleton]]
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[[Category: Muscle protein]]
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[[Category: Nucleotide-binding]]
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[[Category: Structural protein]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]

Revision as of 05:12, 1 August 2013

Template:STRUCTURE 4b1w

Contents

Structure of the Phactr1 RPEL-2 domain bound to actin

Function

[ACTS_RABIT] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. [PHAR1_MOUSE] Binds actin monomers (G actin) and plays a role in the reorganization of the actin cytoskeleton and in formation of actin stress fibers. Plays a role in the formation of tubules by endothelial cells. Regulates PPP1CA activity. Required for normal cell survival (By similarity). Plays a role in cell motility.[1] [2]

About this Structure

4b1w is a 2 chain structure with sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

  1. ↑ Wiezlak M, Diring J, Abella J, Mouilleron S, Way M, McDonald NQ, Treisman R. G-actin regulates the shuttling and PP1 binding of the RPEL protein Phactr1 to control actomyosin assembly. J Cell Sci. 2012 Dec 1;125(Pt 23):5860-72. doi: 10.1242/jcs.112078. Epub 2012 Sep, 12. PMID:22976292 doi:10.1242/jcs.112078
  2. ↑ Mouilleron S, Wiezlak M, O'Reilly N, Treisman R, McDonald NQ. Structures of the Phactr1 RPEL Domain and RPEL Motif Complexes with G-Actin Reveal the Molecular Basis for Actin Binding Cooperativity. Structure. 2012 Oct 2. pii: S0969-2126(12)00335-8. doi:, 10.1016/j.str.2012.08.031. PMID:23041370 doi:10.1016/j.str.2012.08.031

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