4dhs

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'''Unreleased structure'''
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{{STRUCTURE_4dhs| PDB=4dhs | SCENE= }}
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===Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening===
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The entry 4dhs is ON HOLD until Jul 31 2014
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==Function==
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[[http://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
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Authors: Thiel, P., Roeglin, L., Kohlbacher, O., Ottmann, C.
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==About this Structure==
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[[4dhs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DHS OCA].
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Description: Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening
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[[Category: Homo sapiens]]
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[[Category: Kohlbacher, O.]]
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[[Category: Ottmann, C.]]
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[[Category: Roeglin, L.]]
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[[Category: Thiel, P.]]
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[[Category: Adapter protein]]
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[[Category: Helical protein]]
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[[Category: Phosphoprotein binding]]
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[[Category: Protein binding-inhibitor complex]]

Revision as of 05:15, 1 August 2013

Template:STRUCTURE 4dhs

Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening

Function

[1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.

About this Structure

4dhs is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

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OCA

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