4ikc

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'''Unreleased structure'''
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{{STRUCTURE_4ikc| PDB=4ikc | SCENE= }}
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===Crystal Structure of catalytic domain of PTPRQ===
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The entry 4ikc is ON HOLD until Paper Publication
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==Disease==
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[[http://www.uniprot.org/uniprot/PTPRQ_HUMAN PTPRQ_HUMAN]] Autosomal recessive nonsyndromic sensorineural deafness type DFNB. The disease is caused by mutations affecting the gene represented in this entry.
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Authors: Yu, K.R., Ryu, S.E., Kim, S.J.
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==Function==
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[[http://www.uniprot.org/uniprot/PTPRQ_HUMAN PTPRQ_HUMAN]] Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells.<ref>PMID:19351528</ref>
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Description: Crystal Structure of catalytic domain of PTPRQ
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==About this Structure==
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[[4ikc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IKC OCA].
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Kim, S J.]]
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[[Category: Ryu, S E.]]
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[[Category: Yu, K R.]]
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[[Category: Hydrolase]]
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[[Category: Phosphatase]]

Revision as of 05:18, 1 August 2013

Template:STRUCTURE 4ikc

Contents

Crystal Structure of catalytic domain of PTPRQ

Disease

[PTPRQ_HUMAN] Autosomal recessive nonsyndromic sensorineural deafness type DFNB. The disease is caused by mutations affecting the gene represented in this entry.

Function

[PTPRQ_HUMAN] Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells.[1]

About this Structure

4ikc is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Jung H, Kim WK, Kim do H, Cho YS, Kim SJ, Park SG, Park BC, Lim HM, Bae KH, Lee SC. Involvement of PTP-RQ in differentiation during adipogenesis of human mesenchymal stem cells. Biochem Biophys Res Commun. 2009 May 29;383(2):252-7. doi:, 10.1016/j.bbrc.2009.04.001. Epub 2009 Apr 5. PMID:19351528 doi:10.1016/j.bbrc.2009.04.001

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