4jck

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'''Unreleased structure'''
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{{STRUCTURE_4jck| PDB=4jck | SCENE= }}
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===Galectin-3 carbohydrate recognition domain in complex with thioditaloside===
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{{ABSTRACT_PUBMED_23864426}}
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The entry 4jck is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>
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Authors: Bum-Erdene, K., Blanchard, H.
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==About this Structure==
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[[4jck]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JCK OCA].
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Description: Galectin-3 carbohydrate recognition domain in complex with thioditaloside
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==Reference==
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<ref group="xtra">PMID:023864426</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Blanchard, H.]]
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[[Category: Bum-Erdene, K.]]
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[[Category: Beta sandwich]]
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[[Category: Carbohydrate binding protein]]
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[[Category: Sugar binding protein-inhibitor complex]]

Revision as of 05:20, 1 August 2013

Template:STRUCTURE 4jck

Contents

Galectin-3 carbohydrate recognition domain in complex with thioditaloside

Template:ABSTRACT PUBMED 23864426

Function

[LEG3_HUMAN] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.[1] [2] [3]

About this Structure

4jck is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Bum-Erdene K, Gagarinov IA, Collins PM, Winger M, Pearson AG, Wilson JC, Leffler H, Nilsson UJ, Grice ID, Blanchard H. Investigation into the feasibility of thioditaloside as a novel scaffold for galectin-3-specific inhibitors. Chembiochem. 2013 Jul 22;14(11):1331-42. doi: 10.1002/cbic.201300245. PMID:23864426 doi:10.1002/cbic.201300245
  1. ↑ Fukushi J, Makagiansar IT, Stallcup WB. NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin. Mol Biol Cell. 2004 Aug;15(8):3580-90. Epub 2004 Jun 4. PMID:15181153 doi:http://dx.doi.org/10.1091/mbc.E04-03-0236
  2. ↑ Henderson NC, Sethi T. The regulation of inflammation by galectin-3. Immunol Rev. 2009 Jul;230(1):160-71. doi: 10.1111/j.1600-065X.2009.00794.x. PMID:19594635 doi:10.1111/j.1600-065X.2009.00794.x
  3. ↑ Haudek KC, Spronk KJ, Voss PG, Patterson RJ, Wang JL, Arnoys EJ. Dynamics of galectin-3 in the nucleus and cytoplasm. Biochim Biophys Acta. 2010 Feb;1800(2):181-189. Epub 2009 Jul 16. PMID:19616076 doi:S0304-4165(09)00194-9

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