4ksd

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m (Protected "4ksd" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4ksd| PDB=4ksd | SCENE= }}
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===Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain===
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The entry 4ksd is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/MDR1A_MOUSE MDR1A_MOUSE]] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.<ref>PMID:19325113</ref>
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Authors: Ward, A., Szewczyk, P., Grimard, V., Lee, C-W., Martinez, L., Doshi, R., Caya, A., Villaluz, M., Pardon, E., Cregger, C., Swartz, D.J., Falson, P., Urbatsch, I., Govaerts, C., Steyaert, J., Chang, G.
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==About this Structure==
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[[4ksd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lama_glama Lama glama] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSD OCA].
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Description: Crystal structure of MDR transporter 3 with nanobody
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Lama glama]]
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[[Category: Mus musculus]]
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[[Category: Xenobiotic-transporting ATPase]]
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[[Category: Caya, A.]]
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[[Category: Chang, G.]]
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[[Category: Cregger, C.]]
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[[Category: Doshi, R.]]
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[[Category: Falson, P.]]
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[[Category: Govaerts, C.]]
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[[Category: Grimard, V.]]
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[[Category: Lee, C-W.]]
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[[Category: Martinez, L.]]
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[[Category: Pardon, E.]]
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[[Category: Steyaert, J.]]
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[[Category: Swartz, D J.]]
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[[Category: Szewczyk, P.]]
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[[Category: Urbatsch, I.]]
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[[Category: Villaluz, M.]]
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[[Category: Ward, A.]]
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[[Category: Atp binding]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Transport protein]]
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[[Category: Transporter]]

Revision as of 05:23, 1 August 2013

Template:STRUCTURE 4ksd

Contents

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

Function

[MDR1A_MOUSE] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.[1]

About this Structure

4ksd is a 2 chain structure with sequence from Lama glama and Mus musculus. Full crystallographic information is available from OCA.

Reference

  1. ↑ Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science. 2009 Mar 27;323(5922):1718-22. PMID:19325113 doi:323/5922/1718

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OCA

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