2j8k
From Proteopedia
(New page: 200px<br /><applet load="2j8k" size="350" color="white" frame="true" align="right" spinBox="true" caption="2j8k, resolution 1.50Å" /> '''STRUCTURE OF THE FUS...) |
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==Overview== | ==Overview== | ||
| - | The Nostoc punctiforme genes Np275 and Np276 are two adjacently encoded | + | The Nostoc punctiforme genes Np275 and Np276 are two adjacently encoded proteins of 98 and 75 amino acids in length and exhibit sequences composed of tandem pentapeptide repeats. The structures of Np275 and a fusion of Np275 and Np276 were determined to 2.1 and 1.5 A, respectively. The two Nostoc proteins fold as highly symmetric right-handed quadrilateral beta-helices similar to the mycobacterial protein MfpA implicated in fluoroquinolone resistance and DNA gyrase inhibition. The sequence composition of the intervening coding region and the ability to express a fused protein by removing the stop codon for Np275 suggests Np275 and Np276 were recently part of a larger ancestral pentapeptide repeat protein. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Nostoc punctiforme]] | [[Category: Nostoc punctiforme]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Blanchard, J | + | [[Category: Blanchard, J S.]] |
| - | [[Category: Hazleton, K | + | [[Category: Hazleton, K Z.]] |
| - | [[Category: Hegde, S | + | [[Category: Hegde, S S.]] |
| - | [[Category: Vetting, M | + | [[Category: Vetting, M W.]] |
[[Category: MES]] | [[Category: MES]] | ||
[[Category: SO4]] | [[Category: SO4]] | ||
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[[Category: toxin]] | [[Category: toxin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:00:26 2008'' |
Revision as of 16:00, 21 February 2008
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STRUCTURE OF THE FUSION OF NP275 AND NP276, PENTAPEPTIDE REPEAT PROTEINS FROM NOSTOC PUNCTIFORME
Overview
The Nostoc punctiforme genes Np275 and Np276 are two adjacently encoded proteins of 98 and 75 amino acids in length and exhibit sequences composed of tandem pentapeptide repeats. The structures of Np275 and a fusion of Np275 and Np276 were determined to 2.1 and 1.5 A, respectively. The two Nostoc proteins fold as highly symmetric right-handed quadrilateral beta-helices similar to the mycobacterial protein MfpA implicated in fluoroquinolone resistance and DNA gyrase inhibition. The sequence composition of the intervening coding region and the ability to express a fused protein by removing the stop codon for Np275 suggests Np275 and Np276 were recently part of a larger ancestral pentapeptide repeat protein.
About this Structure
2J8K is a Single protein structure of sequence from Nostoc punctiforme with and as ligands. Full crystallographic information is available from OCA.
Reference
Structural characterization of the fusion of two pentapeptide repeat proteins, Np275 and Np276, from Nostoc punctiforme: resurrection of an ancestral protein., Vetting MW, Hegde SS, Hazleton KZ, Blanchard JS, Protein Sci. 2007 Apr;16(4):755-60. PMID:17384236
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