4g01

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[[Image:4g01.jpg|left|200px]]
 
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{{STRUCTURE_4g01| PDB=4g01 | SCENE= }}
{{STRUCTURE_4g01| PDB=4g01 | SCENE= }}
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===ARA7-GDP-Ca2+/VPS9a===
===ARA7-GDP-Ca2+/VPS9a===
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{{ABSTRACT_PUBMED_23519409}}
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==Function==
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[[http://www.uniprot.org/uniprot/VPS9A_ARATH VPS9A_ARATH]] Functions as guanine nucleotide exchange factor (GEF) for Rab small GTPases. Activates specifically RABF1, RABF2A and RABF2B proteins. Required for early stages of embryogenesis, cytokinesis, embryogenesis, and organ development. Is essential for the establishment or maintenance of the polar localization of the auxin efflux carrier PIN1.<ref>PMID:18055610</ref> <ref>PMID:20833725</ref> [[http://www.uniprot.org/uniprot/RAF2B_ARATH RAF2B_ARATH]] Endosomal protein that may be involved in endocytosis.<ref>PMID:20833725</ref>
==About this Structure==
==About this Structure==
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[[4g01]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G01 OCA].
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[[4g01]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] and [http://en.wikipedia.org/wiki/Zasmidium_angulare Zasmidium angulare]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G01 OCA].
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==Reference==
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<ref group="xtra">PMID:023519409</ref><references group="xtra"/><references/>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: Zasmidium angulare]]
[[Category: Ihara, K.]]
[[Category: Ihara, K.]]
[[Category: Divalent metal binding]]
[[Category: Divalent metal binding]]

Revision as of 19:10, 7 August 2013

Template:STRUCTURE 4g01

Contents

ARA7-GDP-Ca2+/VPS9a

Template:ABSTRACT PUBMED 23519409

Function

[VPS9A_ARATH] Functions as guanine nucleotide exchange factor (GEF) for Rab small GTPases. Activates specifically RABF1, RABF2A and RABF2B proteins. Required for early stages of embryogenesis, cytokinesis, embryogenesis, and organ development. Is essential for the establishment or maintenance of the polar localization of the auxin efflux carrier PIN1.[1] [2] [RAF2B_ARATH] Endosomal protein that may be involved in endocytosis.[3]

About this Structure

4g01 is a 2 chain structure with sequence from Arabidopsis thaliana and Zasmidium angulare. Full crystallographic information is available from OCA.

Reference

  • Uejima T, Ihara K, Sunada M, Kawasaki M, Ueda T, Kato R, Nakano A, Wakatsuki S. Direct metal recognition by guanine nucleotide-exchange factor in the initial step of the exchange reaction. Acta Crystallogr D Biol Crystallogr. 2013 Mar;69(Pt 3):345-51. doi:, 10.1107/S0907444912047294. Epub 2013 Feb 16. PMID:23519409 doi:10.1107/S0907444912047294
  1. ↑ Goh T, Uchida W, Arakawa S, Ito E, Dainobu T, Ebine K, Takeuchi M, Sato K, Ueda T, Nakano A. VPS9a, the common activator for two distinct types of Rab5 GTPases, is essential for the development of Arabidopsis thaliana. Plant Cell. 2007 Nov;19(11):3504-15. Epub 2007 Nov 30. PMID:18055610 doi:10.1105/tpc.107.053876
  2. ↑ Uejima T, Ihara K, Goh T, Ito E, Sunada M, Ueda T, Nakano A, Wakatsuki S. GDP-bound and nucleotide-free intermediates of the guanine nucleotide exchange in the Rab5.Vps9 system. J Biol Chem. 2010 Nov 19;285(47):36689-97. Epub 2010 Sep 10. PMID:20833725 doi:10.1074/jbc.M110.152132
  3. ↑ Uejima T, Ihara K, Goh T, Ito E, Sunada M, Ueda T, Nakano A, Wakatsuki S. GDP-bound and nucleotide-free intermediates of the guanine nucleotide exchange in the Rab5.Vps9 system. J Biol Chem. 2010 Nov 19;285(47):36689-97. Epub 2010 Sep 10. PMID:20833725 doi:10.1074/jbc.M110.152132

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