2j9a
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Natural bioactive compounds are of general interest for pharmaceutical | + | Natural bioactive compounds are of general interest for pharmaceutical research because they may serve as leads in drug development campaigns. Among them, microginins are linear peptides known to inhibit various exopeptidases. The crystal structure of microginin FR1 from Microcystis sp. bound to bovine lens leucine aminopeptidase was established at 1.73 Angstrom resolution. The observed binding structure could be beneficial for the design of potent aminopeptidase inhibitors. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Kraft, M.]] | [[Category: Kraft, M.]] | ||
[[Category: Schleberger, C.]] | [[Category: Schleberger, C.]] | ||
| - | [[Category: Schulz, G | + | [[Category: Schulz, G E.]] |
[[Category: Weckesser, J.]] | [[Category: Weckesser, J.]] | ||
[[Category: AHY]] | [[Category: AHY]] | ||
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[[Category: protease]] | [[Category: protease]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:00:39 2008'' |
Revision as of 16:00, 21 February 2008
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BLLAP IN COMPLEX WITH MICROGININ FR1
Overview
Natural bioactive compounds are of general interest for pharmaceutical research because they may serve as leads in drug development campaigns. Among them, microginins are linear peptides known to inhibit various exopeptidases. The crystal structure of microginin FR1 from Microcystis sp. bound to bovine lens leucine aminopeptidase was established at 1.73 Angstrom resolution. The observed binding structure could be beneficial for the design of potent aminopeptidase inhibitors.
About this Structure
2J9A is a Single protein structure of sequence from Bos taurus and Microcystis sp. with , , , and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Binding structure of the leucine aminopeptidase inhibitor microginin FR1., Kraft M, Schleberger C, Weckesser J, Schulz GE, FEBS Lett. 2006 Dec 22;580(30):6943-7. Epub 2006 Dec 4. PMID:17157838
Page seeded by OCA on Thu Feb 21 18:00:39 2008
Categories: Bos taurus | Microcystis sp. | Single protein | Kraft, M. | Schleberger, C. | Schulz, G E. | Weckesser, J. | AHY | CL | DMS | MPD | ZN | Acetylation | Aminopeptidase | Inhibitor complex hydrolase | Leucine aminopeptidase | Metal-binding | Microcystins | Microginin | Protease
