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3aod

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[[Image:3aod.png|left|200px]]
 
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{{STRUCTURE_3aod| PDB=3aod | SCENE= }}
{{STRUCTURE_3aod| PDB=3aod | SCENE= }}
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===Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket===
===Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket===
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{{ABSTRACT_PUBMED_22121023}}
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==Function==
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[[http://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI]] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref>
==About this Structure==
==About this Structure==
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[[3aod]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AOD OCA].
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[[3aod]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AOD OCA].
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[[Category: Escherichia coli]]
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==Reference==
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<ref group="xtra">PMID:022121023</ref><references group="xtra"/><references/>
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[[Category: Escherichia coli k-12]]
[[Category: Nakashima, R.]]
[[Category: Nakashima, R.]]
[[Category: Sakurai, K.]]
[[Category: Sakurai, K.]]

Revision as of 19:21, 7 August 2013

Template:STRUCTURE 3aod

Contents

Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket

Template:ABSTRACT PUBMED 22121023

Function

[ACRB_ECOLI] AcrAB is a drug efflux protein with a broad substrate specificity.[1] [2] [3]

About this Structure

3aod is a 3 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.

Reference

  • Nakashima R, Sakurai K, Yamasaki S, Nishino K, Yamaguchi A. Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket. Nature. 2011 Nov 27;480(7378):565-9. doi: 10.1038/nature10641. PMID:22121023 doi:10.1038/nature10641
  1. ↑ Murakami S, Nakashima R, Yamashita E, Matsumoto T, Yamaguchi A. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature. 2006 Sep 14;443(7108):173-9. Epub 2006 Aug 16. PMID:16915237 doi:10.1038/nature05076
  2. ↑ Seeger MA, Schiefner A, Eicher T, Verrey F, Diederichs K, Pos KM. Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism. Science. 2006 Sep 1;313(5791):1295-8. PMID:16946072 doi:313/5791/1295
  3. ↑ Sennhauser G, Amstutz P, Briand C, Storchenegger O, Grutter MG. Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors. PLoS Biol. 2007 Jan;5(1):e7. PMID:17194213 doi:10.1371/journal.pbio.0050007

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