2w8q

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
{{STRUCTURE_2w8q| PDB=2w8q | SCENE= }}
{{STRUCTURE_2w8q| PDB=2w8q | SCENE= }}
-
===THE CRYSTAL STRUCTURE OF HUMAN SSADH IN COMPLEX WITH SSA.===
+
===The crystal structure of human SSADH in complex with SSA.===
{{ABSTRACT_PUBMED_19300440}}
{{ABSTRACT_PUBMED_19300440}}
Line 7: Line 7:
==Function==
==Function==
-
[[http://www.uniprot.org/uniprot/SSDH_HUMAN SSDH_HUMAN]] Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).<ref>PMID:19300440</ref>
+
[[http://www.uniprot.org/uniprot/SSDH_HUMAN SSDH_HUMAN]] Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).<ref>PMID:19300440</ref>
==About this Structure==
==About this Structure==
Line 18: Line 18:
<ref group="xtra">PMID:019300440</ref><references group="xtra"/><references/>
<ref group="xtra">PMID:019300440</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Succinate-semialdehyde dehydrogenase]]
 
[[Category: Kim, K J.]]
[[Category: Kim, K J.]]
[[Category: Kim, Y G.]]
[[Category: Kim, Y G.]]

Revision as of 19:22, 7 August 2013

Template:STRUCTURE 2w8q

Contents

The crystal structure of human SSADH in complex with SSA.

Template:ABSTRACT PUBMED 19300440

Disease

[SSDH_HUMAN] Defects in ALDH5A1 are the cause of succinate semialdehyde dehydrogenase deficiency (SSADH deficiency) [MIM:271980]. SSADH deficiency is a rare inborn error in the metabolism of 4-aminobutyric acid (GABA) which leads to accumulation of 4-hydroxybutyric acid in physiologic fluids of patients. The disease is characterized by severe ataxia and by mildly retarded psychomotor development.

Function

[SSDH_HUMAN] Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).[1]

About this Structure

2w8q is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Kim YG, Lee S, Kwon OS, Park SY, Lee SJ, Park BJ, Kim KJ. Redox-switch modulation of human SSADH by dynamic catalytic loop. EMBO J. 2009 Apr 8;28(7):959-68. Epub 2009 Mar 19. PMID:19300440 doi:10.1038/emboj.2009.40
  1. ↑ Kim YG, Lee S, Kwon OS, Park SY, Lee SJ, Park BJ, Kim KJ. Redox-switch modulation of human SSADH by dynamic catalytic loop. EMBO J. 2009 Apr 8;28(7):959-68. Epub 2009 Mar 19. PMID:19300440 doi:10.1038/emboj.2009.40

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2w8q"
Personal tools