4ef6
From Proteopedia
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{{STRUCTURE_4ef6| PDB=4ef6 | SCENE= }} | {{STRUCTURE_4ef6| PDB=4ef6 | SCENE= }} | ||
===Crystal Structure of Mycobacterium tuberculosis Pantothenate synthetase in complex with fragment 1=== | ===Crystal Structure of Mycobacterium tuberculosis Pantothenate synthetase in complex with fragment 1=== | ||
| + | {{ABSTRACT_PUBMED_23872845}} | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/PANC_MYCTU PANC_MYCTU]] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.<ref>PMID:11669627</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[4ef6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EF6 OCA]. | [[4ef6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EF6 OCA]. | ||
| + | |||
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023872845</ref><references group="xtra"/><references/> | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Pantoate--beta-alanine ligase]] | [[Category: Pantoate--beta-alanine ligase]] | ||
Revision as of 19:25, 7 August 2013
Contents |
Crystal Structure of Mycobacterium tuberculosis Pantothenate synthetase in complex with fragment 1
Template:ABSTRACT PUBMED 23872845
Function
[PANC_MYCTU] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.[1]
About this Structure
4ef6 is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.
Reference
- Silvestre HL, Blundell TL, Abell C, Ciulli A. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery. Proc Natl Acad Sci U S A. 2013 Jul 19. PMID:23872845 doi:10.1073/pnas.1304045110
