3w0s

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'''Unreleased structure'''
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{{STRUCTURE_3w0s| PDB=3w0s | SCENE= }}
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===Crystal structure of aminoglycoside phosphotransferase APH(4)-Ia, ternary complex with AMP-PNP and hygromycin B===
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{{ABSTRACT_PUBMED_23747390}}
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The entry 3w0s is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/KHYB_ECOLX KHYB_ECOLX]] The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation. Only phosphorylates hygromycin and closely related compounds such as demethyl analogs and destomycin.
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Authors: Iino, D., Takakura, Y., Fukano, K., Sasaki, Y., Hoshino, T., Ohsawa, K., Nakamura, A., Yajima, S.
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==About this Structure==
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[[3w0s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W0S OCA].
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Description: Crystal structure of aminoglycoside phosphotransferase APH(4)-Ia, ternary complex with AMP-PNP and hygromycin B
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==Reference==
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<ref group="xtra">PMID:023747390</ref><references group="xtra"/><references/>
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[[Category: Escherichia coli]]
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[[Category: Hygromycin B 4-O-kinase]]
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[[Category: Fukano, K.]]
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[[Category: Hoshino, T.]]
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[[Category: Iino, D.]]
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[[Category: Nakamura, A.]]
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[[Category: Ohsawa, K.]]
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[[Category: Sasaki, Y.]]
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[[Category: Takakura, Y.]]
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[[Category: Yajima, S.]]
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[[Category: Phosphotransferase]]
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[[Category: Transferase-antibiotic complex]]

Revision as of 20:49, 7 August 2013

Template:STRUCTURE 3w0s

Contents

Crystal structure of aminoglycoside phosphotransferase APH(4)-Ia, ternary complex with AMP-PNP and hygromycin B

Template:ABSTRACT PUBMED 23747390

Function

[KHYB_ECOLX] The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation. Only phosphorylates hygromycin and closely related compounds such as demethyl analogs and destomycin.

About this Structure

3w0s is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

  • Iino D, Takakura Y, Fukano K, Sasaki Y, Hoshino T, Ohsawa K, Nakamura A, Yajima S. Crystal structures of the ternary complex of APH(4)-Ia/Hph with hygromycin B and an ATP analog using a thermostable mutant. J Struct Biol. 2013 Jul;183(1):76-85. doi: 10.1016/j.jsb.2013.05.023. Epub 2013, Jun 7. PMID:23747390 doi:10.1016/j.jsb.2013.05.023

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OCA

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