3w0q

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_3w0q| PDB=3w0q | SCENE= }}
 +
===Crystal structure of a thermostable mutant of aminoglycoside phosphotransferase APH(4)-Ia (N203A), ternary complex with AMP-PNP and hygromycin B===
 +
{{ABSTRACT_PUBMED_23747390}}
-
The entry 3w0q is ON HOLD until Paper Publication
+
==Function==
 +
[[http://www.uniprot.org/uniprot/KHYB_ECOLX KHYB_ECOLX]] The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation. Only phosphorylates hygromycin and closely related compounds such as demethyl analogs and destomycin.
-
Authors: Iino, D., Takakura, Y., Fukano, K., Sasaki, Y., Hoshino, T., Ohsawa, K., Nakamura, A., Yajima, S.
+
==About this Structure==
 +
[[3w0q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W0Q OCA].
-
Description: Crystal structure of a thermostable mutant of aminoglycoside phosphotransferase APH(4)-Ia (N203A), ternary complex with AMP-PNP and hygromycin B
+
==Reference==
 +
<ref group="xtra">PMID:023747390</ref><references group="xtra"/><references/>
 +
[[Category: Escherichia coli]]
 +
[[Category: Hygromycin B 4-O-kinase]]
 +
[[Category: Fukano, K.]]
 +
[[Category: Hoshino, T.]]
 +
[[Category: Iino, D.]]
 +
[[Category: Nakamura, A.]]
 +
[[Category: Ohsawa, K.]]
 +
[[Category: Sasaki, Y.]]
 +
[[Category: Takakura, Y.]]
 +
[[Category: Yajima, S.]]
 +
[[Category: Phosphotransferase]]
 +
[[Category: Transferase-antibiotic complex]]

Revision as of 20:50, 7 August 2013

Template:STRUCTURE 3w0q

Contents

Crystal structure of a thermostable mutant of aminoglycoside phosphotransferase APH(4)-Ia (N203A), ternary complex with AMP-PNP and hygromycin B

Template:ABSTRACT PUBMED 23747390

Function

[KHYB_ECOLX] The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation. Only phosphorylates hygromycin and closely related compounds such as demethyl analogs and destomycin.

About this Structure

3w0q is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

  • Iino D, Takakura Y, Fukano K, Sasaki Y, Hoshino T, Ohsawa K, Nakamura A, Yajima S. Crystal structures of the ternary complex of APH(4)-Ia/Hph with hygromycin B and an ATP analog using a thermostable mutant. J Struct Biol. 2013 Jul;183(1):76-85. doi: 10.1016/j.jsb.2013.05.023. Epub 2013, Jun 7. PMID:23747390 doi:10.1016/j.jsb.2013.05.023

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3w0q"
Personal tools