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4li1

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'''Unreleased structure'''
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{{STRUCTURE_4li1| PDB=4li1 | SCENE= }}
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===Crystal Structures of Lgr4 and its complex with R-spondin1===
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{{ABSTRACT_PUBMED_23891289}}
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The entry 4li1 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/LGR4_XENTR LGR4_XENTR]] Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye.
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Authors: Xu, Y., Rajashankar, K., Robev, D.
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==About this Structure==
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[[4li1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_(silurana)_tropicalis Xenopus (silurana) tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LI1 OCA].
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Description: Crystal Structures of Lgr4 and its complex with R-spondin1
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==Reference==
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<ref group="xtra">PMID:023891289</ref><references group="xtra"/><references/>
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[[Category: Rajashankar, K.]]
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[[Category: Robev, D.]]
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[[Category: Xu, Y.]]
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[[Category: Hormone receptor]]
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[[Category: Lrr]]

Revision as of 20:55, 7 August 2013

Template:STRUCTURE 4li1

Contents

Crystal Structures of Lgr4 and its complex with R-spondin1

Template:ABSTRACT PUBMED 23891289

Function

[LGR4_XENTR] Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye.

About this Structure

4li1 is a 2 chain structure with sequence from Xenopus (silurana) tropicalis. Full crystallographic information is available from OCA.

Reference

  • Xu K, Xu Y, Rajashankar KR, Robev D, Nikolov DB. Crystal Structures of Lgr4 and Its Complex with R-Spondin1. Structure. 2013 Jul 23. pii: S0969-2126(13)00242-6. doi:, 10.1016/j.str.2013.07.001. PMID:23891289 doi:10.1016/j.str.2013.07.001

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OCA

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