4km6

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'''Unreleased structure'''
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{{STRUCTURE_4km6| PDB=4km6 | SCENE= }}
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===Human folate receptor alpha (FOLR1) at acidic pH, orthorhombic form===
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The entry 4km6 is ON HOLD
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==Disease==
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[[http://www.uniprot.org/uniprot/FOLR1_HUMAN FOLR1_HUMAN]] Neurodegenerative syndrome due to cerebral folate transport deficiency. Neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:[http://omim.org/entry/613068 613068]]: A neurodegenerative disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy and leukodystrophy. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Authors: Singh, M., Dann III, C.E.
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==Function==
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[[http://www.uniprot.org/uniprot/FOLR1_HUMAN FOLR1_HUMAN]] Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
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Description: Human folate receptor alpha (FOLR1) at acidic pH, orthorhombic form
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==About this Structure==
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[[4km6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KM6 OCA].
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[[Category: Homo sapiens]]
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[[Category: III, C E.Dann.]]
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[[Category: Singh, M.]]
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[[Category: 5-methyltetrahydrofolate]]
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[[Category: Antifolate]]
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[[Category: Folate receptor]]
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[[Category: Folate receptor alpha]]
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[[Category: Folate-conjugate]]
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[[Category: Folate]]
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[[Category: Folic acid]]
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[[Category: Folr1]]
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[[Category: Gpi-anchored protein on eukaryotic membrane]]
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[[Category: Membrane protein]]
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[[Category: Transport protein]]

Revision as of 21:03, 7 August 2013

Template:STRUCTURE 4km6

Contents

Human folate receptor alpha (FOLR1) at acidic pH, orthorhombic form

Disease

[FOLR1_HUMAN] Neurodegenerative syndrome due to cerebral folate transport deficiency. Neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:613068]: A neurodegenerative disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy and leukodystrophy. Note=The disease is caused by mutations affecting the gene represented in this entry.

Function

[FOLR1_HUMAN] Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.

About this Structure

4km6 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Proteopedia Page Contributors and Editors (what is this?)

OCA

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