4lrg

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m (Protected "4lrg" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4lrg| PDB=4lrg | SCENE= }}
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===Structure of BRD4 bromodomain 1 with a dimethyl thiophene isoxazole azepine carboxamide===
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The entry 4lrg is ON HOLD
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==Disease==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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Authors: Bellon, S., Poy, F., Jayaram, H., Gehling, V., Hewitt, M., Vaswani, R., Leblanc, Y., Cote, A., Nasveschuk, C., Taylor, A., Harmange, J.-C., Audia, J., Pardo, E., Joshi, S., Sandy, P., Mertz, J., Sims, R., Bergeron, L., Bryant, B., Sankaranarayanan, R., Yellapuntala, S., Nandana, B.S., Birudukota, S., Albrecht, B.
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==Function==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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Description: Structure of BRD4 bromodomain 1 with a 3-methyl-4-phenylisoxazol-5-amine fragment
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==About this Structure==
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[[4lrg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRG OCA].
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Albrecht, B.]]
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[[Category: Audia, J.]]
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[[Category: Bellon, S.]]
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[[Category: Bergeron, L.]]
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[[Category: Birudukota, S.]]
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[[Category: Bryant, B.]]
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[[Category: Cote, A.]]
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[[Category: Gehling, V.]]
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[[Category: Harmange, J C.]]
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[[Category: Hewitt, M.]]
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[[Category: Jayaram, H.]]
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[[Category: Joshi, S.]]
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[[Category: Leblanc, Y.]]
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[[Category: Mertz, J.]]
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[[Category: Nandana, B S.]]
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[[Category: Nasveschuk, C.]]
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[[Category: Pardo, E.]]
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[[Category: Poy, F.]]
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[[Category: Sandy, P.]]
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[[Category: Sankaranarayanan, R.]]
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[[Category: Sims, R.]]
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[[Category: Taylor, A.]]
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[[Category: Vaswani, R.]]
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[[Category: Yellapuntala, S.]]
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[[Category: Bet inhibitor]]
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[[Category: Brd4 first bromodomain]]
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[[Category: Transcription regulator-inhibitor complex]]

Revision as of 21:20, 7 August 2013

Template:STRUCTURE 4lrg

Contents

Structure of BRD4 bromodomain 1 with a dimethyl thiophene isoxazole azepine carboxamide

Disease

[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]

Function

[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

About this Structure

4lrg is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
  2. ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

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OCA

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