3vw7

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[[Image:3vw7.jpg|left|200px]]
 
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{{STRUCTURE_3vw7| PDB=3vw7 | SCENE= }}
{{STRUCTURE_3vw7| PDB=3vw7 | SCENE= }}
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===Crystal structure of human protease-activated receptor 1 (PAR1) bound with antagonist vorapaxar at 2.2 angstrom===
===Crystal structure of human protease-activated receptor 1 (PAR1) bound with antagonist vorapaxar at 2.2 angstrom===
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{{ABSTRACT_PUBMED_23222541}}
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==Function==
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[[http://www.uniprot.org/uniprot/PAR1_HUMAN PAR1_HUMAN]] High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.<ref>PMID:10079109</ref>
==About this Structure==
==About this Structure==
[[3vw7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VW7 OCA].
[[3vw7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VW7 OCA].
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==Reference==
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<ref group="xtra">PMID:023222541</ref><references group="xtra"/><references/>
[[Category: Lysozyme]]
[[Category: Lysozyme]]
[[Category: Arlow, D H.]]
[[Category: Arlow, D H.]]

Revision as of 06:35, 14 August 2013

Template:STRUCTURE 3vw7

Contents

Crystal structure of human protease-activated receptor 1 (PAR1) bound with antagonist vorapaxar at 2.2 angstrom

Template:ABSTRACT PUBMED 23222541

Function

[PAR1_HUMAN] High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.[1]

About this Structure

3vw7 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Zhang C, Srinivasan Y, Arlow DH, Fung JJ, Palmer D, Zheng Y, Green HF, Pandey A, Dror RO, Shaw DE, Weis WI, Coughlin SR, Kobilka BK. High-resolution crystal structure of human protease-activated receptor 1. Nature. 2012 Dec 20;492(7429):387-92. doi: 10.1038/nature11701. Epub 2012 Dec 9. PMID:23222541 doi:10.1038/nature11701
  1. ↑ Kahn ML, Nakanishi-Matsui M, Shapiro MJ, Ishihara H, Coughlin SR. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J Clin Invest. 1999 Mar;103(6):879-87. PMID:10079109 doi:10.1172/JCI6042

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