2jm6
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Apoptosis is held in check by prosurvival proteins of the Bcl-2 family. | + | Apoptosis is held in check by prosurvival proteins of the Bcl-2 family. The distantly related BH3-only proteins bind to and antagonize them, thereby promoting apoptosis. Whereas binding of the BH3-only protein Noxa to prosurvival Mcl-1 induces Mcl-1 degradation by the proteasome, binding of another BH3-only ligand, Bim, elevates Mcl-1 protein levels. We compared the three-dimensional structures of the complexes formed between BH3 peptides of both Bim and Noxa, and we show that a discrete C-terminal sequence of the Noxa BH3 is necessary to instigate Mcl-1 degradation. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Colman, P | + | [[Category: Colman, P M.]] |
| - | [[Category: Czabotar, P | + | [[Category: Czabotar, P E.]] |
| - | [[Category: Day, C | + | [[Category: Day, C L.]] |
| - | [[Category: Delft, M | + | [[Category: Delft, M F.van.]] |
| - | [[Category: Fairlie, W | + | [[Category: Fairlie, W D.]] |
| - | [[Category: Hinds, M | + | [[Category: Hinds, M G.]] |
| - | [[Category: Huang, D | + | [[Category: Huang, D C.S.]] |
| - | [[Category: Lee, E | + | [[Category: Lee, E F.]] |
| - | [[Category: Smith, B | + | [[Category: Smith, B J.]] |
[[Category: apoptosis]] | [[Category: apoptosis]] | ||
[[Category: bcl-2]] | [[Category: bcl-2]] | ||
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[[Category: mcl-1]] | [[Category: mcl-1]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:03:58 2008'' |
Revision as of 16:03, 21 February 2008
|
Solution structure of MCL-1 complexed with NOXAB
Overview
Apoptosis is held in check by prosurvival proteins of the Bcl-2 family. The distantly related BH3-only proteins bind to and antagonize them, thereby promoting apoptosis. Whereas binding of the BH3-only protein Noxa to prosurvival Mcl-1 induces Mcl-1 degradation by the proteasome, binding of another BH3-only ligand, Bim, elevates Mcl-1 protein levels. We compared the three-dimensional structures of the complexes formed between BH3 peptides of both Bim and Noxa, and we show that a discrete C-terminal sequence of the Noxa BH3 is necessary to instigate Mcl-1 degradation.
About this Structure
2JM6 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structural insights into the degradation of Mcl-1 induced by BH3 domains., Czabotar PE, Lee EF, van Delft MF, Day CL, Smith BJ, Huang DC, Fairlie WD, Hinds MG, Colman PM, Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6217-22. Epub 2007 Mar 27. PMID:17389404
Page seeded by OCA on Thu Feb 21 18:03:58 2008
Categories: Mus musculus | Protein complex | Colman, P M. | Czabotar, P E. | Day, C L. | Delft, M F.van. | Fairlie, W D. | Hinds, M G. | Huang, D C.S. | Lee, E F. | Smith, B J. | Apoptosis | Bcl-2 | Bh3-only | Helical bundle | Mcl-1
