4jcf

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'''Unreleased structure'''
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{{STRUCTURE_4jcf| PDB=4jcf | SCENE= }}
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===S268F Variant of JC Polyomavirus Major Capsid Protein VP1 in Complex with LSTc===
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{{ABSTRACT_PUBMED_23760462}}
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The entry 4jcf is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/VP1_POVJC VP1_POVJC]] Forms an icosahedral capsid with a T=7 symmetry and a 40 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins. Interacts with a N-linked glycoprotein containing terminal alpha(2-6)-linked sialic acids on the cell surface to provide virion attachment to target cell. The serotonergic receptor 5HT2AR also acts as a cellular receptor for JCV on human glial cells. Once attached, the virions enter predominantly by a ligand-inducible clathrin-dependent pathway and traffic to the ER. Inside the endoplasmic reticulum, the protein folding machinery isomerizes VP1 interpentamer disulfide bonds, thereby triggering initial uncoating. Next, the virion uses the endoplasmic reticulum-associated degradation machinery to probably translocate in the cytosol before reaching the nucleus. Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2/Vp3 nuclear localization signal. In late phase of infection, neo-synthesized VP1 encapsulates replicated genomic DNA at nuclear domains called promyelocytic leukemia (PML) bodies, and participates in rearranging nucleosomes around the viral DNA.<ref>PMID:10666259</ref>
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Authors: Stehle, T., Stroh, L.J.
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==About this Structure==
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[[4jcf]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Jc_polyomavirus Jc polyomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JCF OCA].
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Description: S268F Variant of JC Polyomavirus Major Capsid Protein VP1 in Complex with LSTc
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==Reference==
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<ref group="xtra">PMID:023760462</ref><references group="xtra"/><references/>
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[[Category: Jc polyomavirus]]
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[[Category: Stehle, T.]]
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[[Category: Stroh, L J.]]
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[[Category: Beta-sandwich]]
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[[Category: Jelly roll topology]]
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[[Category: Lstc receptor motif]]
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[[Category: Major capsid protein]]
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[[Category: Pml-associated vp1 mutation]]
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[[Category: Viral protein]]

Revision as of 07:49, 14 August 2013

Template:STRUCTURE 4jcf

Contents

S268F Variant of JC Polyomavirus Major Capsid Protein VP1 in Complex with LSTc

Template:ABSTRACT PUBMED 23760462

Function

[VP1_POVJC] Forms an icosahedral capsid with a T=7 symmetry and a 40 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins. Interacts with a N-linked glycoprotein containing terminal alpha(2-6)-linked sialic acids on the cell surface to provide virion attachment to target cell. The serotonergic receptor 5HT2AR also acts as a cellular receptor for JCV on human glial cells. Once attached, the virions enter predominantly by a ligand-inducible clathrin-dependent pathway and traffic to the ER. Inside the endoplasmic reticulum, the protein folding machinery isomerizes VP1 interpentamer disulfide bonds, thereby triggering initial uncoating. Next, the virion uses the endoplasmic reticulum-associated degradation machinery to probably translocate in the cytosol before reaching the nucleus. Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2/Vp3 nuclear localization signal. In late phase of infection, neo-synthesized VP1 encapsulates replicated genomic DNA at nuclear domains called promyelocytic leukemia (PML) bodies, and participates in rearranging nucleosomes around the viral DNA.[1]

About this Structure

4jcf is a 5 chain structure with sequence from Jc polyomavirus. Full crystallographic information is available from OCA.

Reference

  • Maginnis MS, Stroh LJ, Gee GV, O'Hara BA, Derdowski A, Stehle T, Atwood WJ. Progressive multifocal leukoencephalopathy-associated mutations in the JC polyomavirus capsid disrupt lactoseries tetrasaccharide c binding. MBio. 2013 Jun 11;4(3):e00247-13. doi: 10.1128/mBio.00247-13. PMID:23760462 doi:10.1128/mBio.00247-13
  1. ↑ Pho MT, Ashok A, Atwood WJ. JC virus enters human glial cells by clathrin-dependent receptor-mediated endocytosis. J Virol. 2000 Mar;74(5):2288-92. PMID:10666259

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