4kfp

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'''Unreleased structure'''
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{{STRUCTURE_4kfp| PDB=4kfp | SCENE= }}
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===Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived Ureas as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)===
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{{ABSTRACT_PUBMED_23899614}}
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The entry 4kfp is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
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Authors: Dragovich, P.S., Bair, K.W., Baumeister, T., Ho, Y., Liederer, B.M., Liu, X., O'Brien, T., Oeh, J., Sampath, D., Skelton, N., Wang, L., Wang, W., Wu, H., Xiao, Y., Yuen, P., Zak, M., Zhang, L., Zheng, X.
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==About this Structure==
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[[4kfp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KFP OCA].
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Description: Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived Ureas as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
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==Reference==
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<ref group="xtra">PMID:023899614</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Nicotinamide phosphoribosyltransferase]]
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[[Category: Bair, K W.]]
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[[Category: Baumeister, T.]]
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[[Category: Brien, T O.]]
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[[Category: Dragovich, P S.]]
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[[Category: Ho, Y.]]
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[[Category: Liederer, B M.]]
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[[Category: Liu, X.]]
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[[Category: Oeh, J.]]
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[[Category: Sampath, D.]]
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[[Category: Skelton, N.]]
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[[Category: Wang, L.]]
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[[Category: Wang, W.]]
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[[Category: Wu, H.]]
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[[Category: Xiao, Y.]]
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[[Category: Yuen, P.]]
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[[Category: Zak, M.]]
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[[Category: Zhang, L.]]
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[[Category: Zheng, X.]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 07:51, 14 August 2013

Template:STRUCTURE 4kfp

Contents

Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived Ureas as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)

Template:ABSTRACT PUBMED 23899614

Function

[NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).

About this Structure

4kfp is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Dragovich PS, Bair KW, Baumeister T, Ho YC, Liederer BM, Liu X, Liu Y, O'Brien T, Oeh J, Sampath D, Skelton N, Wang L, Wang W, Wu H, Xiao Y, Yuen PW, Zak M, Zhang L, Zheng X. Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg Med Chem Lett. 2013 Sep 1;23(17):4875-85. doi: 10.1016/j.bmcl.2013.06.090., Epub 2013 Jul 6. PMID:23899614 doi:10.1016/j.bmcl.2013.06.090

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OCA

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