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4lfs

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4lfs| PDB=4lfs | SCENE= }}
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===High resolution x-ray structure of racemic ShK toxin===
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{{ABSTRACT_PUBMED_23919482}}
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The entry 4lfs is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/TXSHK_STOHE TXSHK_STOHE]] Inhibits voltage-dependent potassium channels. Inhibits Kv1.3/KCNA3 potently and also blocks Kv1.1/KCNA1, Kv1.4/KCNA4, and Kv1.6/KCNA6 at subnanomolar concentrations.<ref>PMID:7660365</ref>
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Authors: Dang, B., Kubota, T., Mandal, K., Bezanilla, F., Kent, S.B.H.
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==About this Structure==
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[[4lfs]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LFS OCA].
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Description: High resolution x-ray structure of racemic ShK toxin
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==Reference==
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<ref group="xtra">PMID:023919482</ref><references group="xtra"/><references/>
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[[Category: Bezanilla, F.]]
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[[Category: Dang, B.]]
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[[Category: Kent, S B.H.]]
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[[Category: Kubota, T.]]
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[[Category: Mandal, K.]]
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[[Category: Chemical protein synthesis]]
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[[Category: Racemic protein crystallography]]
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[[Category: Shk toxin]]
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[[Category: Toxin]]

Revision as of 07:53, 14 August 2013

Template:STRUCTURE 4lfs

Contents

High resolution x-ray structure of racemic ShK toxin

Template:ABSTRACT PUBMED 23919482

Function

[TXSHK_STOHE] Inhibits voltage-dependent potassium channels. Inhibits Kv1.3/KCNA3 potently and also blocks Kv1.1/KCNA1, Kv1.4/KCNA4, and Kv1.6/KCNA6 at subnanomolar concentrations.[1]

About this Structure

4lfs is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Dang B, Kubota T, Mandal K, Bezanilla F, Kent SB. Native Chemical Ligation at Asx-Cys, Glx-Cys: Chemical Synthesis and High-Resolution X-ray Structure of ShK Toxin by Racemic Protein Crystallography. J Am Chem Soc. 2013 Aug 6. PMID:23919482 doi:10.1021/ja4046795
  1. ↑ Castaneda O, Sotolongo V, Amor AM, Stocklin R, Anderson AJ, Harvey AL, Engstrom A, Wernstedt C, Karlsson E. Characterization of a potassium channel toxin from the Caribbean Sea anemone Stichodactyla helianthus. Toxicon. 1995 May;33(5):603-13. PMID:7660365

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