4gvj

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'''Unreleased structure'''
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{{STRUCTURE_4gvj| PDB=4gvj | SCENE= }}
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===Tyk2 (JH1) in complex with adenosine di-phosphate===
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{{ABSTRACT_PUBMED_23867602}}
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The entry 4gvj is ON HOLD until Paper Publication
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==Disease==
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[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:[http://omim.org/entry/611521 611521]]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
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Authors: Liang, J., Abbema, A.V., Bao, L., Barrett, K., Beresini, M., Berezhkovskiy, L., Blair, W., Chang, C., Driscoll, J., Eigenbrot, C., Ghilardi, N., Gibbons, P., Halladay, J., Johnson, A., Kohli, P.B., Lai, Y., Liimatta, M., Mantik, P., Menghrajani, K., Murray, J., Sambrone, A., Shao, Y., Shia, S., Shin, Y., Smith, J., Sohn, S., Stanley, M., Tsui, V., Ultsch, M., Wu, L., Zhang, B., Magnuson, S.
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==Function==
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[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.<ref>PMID:7526154</ref>
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Description: Tyk2 (JH1) in complex with adenosine di-phosphate
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==About this Structure==
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[[4gvj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GVJ OCA].
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==Reference==
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<ref group="xtra">PMID:023867602</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Non-specific protein-tyrosine kinase]]
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[[Category: Abbema, A V.]]
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[[Category: Bao, L.]]
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[[Category: Barrett, K.]]
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[[Category: Beresini, M.]]
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[[Category: Berezhkovskiy, L.]]
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[[Category: Blair, W.]]
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[[Category: Chang, C.]]
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[[Category: Driscoll, J.]]
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[[Category: Eigenbrot, C.]]
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[[Category: Ghilardi, N.]]
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[[Category: Gibbons, P.]]
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[[Category: Halladay, J.]]
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[[Category: Johnson, A.]]
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[[Category: Kohli, P B.]]
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[[Category: Lai, Y.]]
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[[Category: Liang, J.]]
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[[Category: Liimatta, M.]]
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[[Category: Magnuson, S.]]
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[[Category: Mantik, P.]]
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[[Category: Menghrajani, K.]]
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[[Category: Murray, J.]]
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[[Category: Sambrone, A.]]
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[[Category: Shao, Y.]]
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[[Category: Shia, S.]]
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[[Category: Shin, Y.]]
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[[Category: Smith, J.]]
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[[Category: Sohn, S.]]
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[[Category: Stanley, M.]]
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[[Category: Tsui, V.]]
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[[Category: Ultsch, M.]]
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[[Category: Wu, L.]]
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[[Category: Zhang, B.]]
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[[Category: Hydrolase]]
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[[Category: Kinase]]

Revision as of 07:55, 14 August 2013

Template:STRUCTURE 4gvj

Contents

Tyk2 (JH1) in complex with adenosine di-phosphate

Template:ABSTRACT PUBMED 23867602

Disease

[TYK2_HUMAN] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.

Function

[TYK2_HUMAN] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.[1]

About this Structure

4gvj is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Liang J, Tsui V, Van Abbema A, Bao L, Barrett K, Beresini M, Berezhkovskiy L, Blair WS, Chang C, Driscoll J, Eigenbrot C, Ghilardi N, Gibbons P, Halladay J, Johnson A, Kohli PB, Lai Y, Liimatta M, Mantik P, Menghrajani K, Murray J, Sambrone A, Xiao Y, Shia S, Shin Y, Smith J, Sohn S, Stanley M, Ultsch M, Zhang B, Wu LC, Magnuson S. Lead identification of novel and selective TYK2 inhibitors. Eur J Med Chem. 2013 May 14;67C:175-187. doi: 10.1016/j.ejmech.2013.03.070. PMID:23867602 doi:10.1016/j.ejmech.2013.03.070
  1. ↑ Colamonici O, Yan H, Domanski P, Handa R, Smalley D, Mullersman J, Witte M, Krishnan K, Krolewski J. Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase. Mol Cell Biol. 1994 Dec;14(12):8133-42. PMID:7526154

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