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4k30

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'''Unreleased structure'''
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{{STRUCTURE_4k30| PDB=4k30 | SCENE= }}
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===Structure of the N-acetyltransferase domain of human N-acetylglutamate synthase===
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{{ABSTRACT_PUBMED_23894642}}
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The entry 4k30 is ON HOLD until Paper Publication
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==Disease==
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[[http://www.uniprot.org/uniprot/NAGS_HUMAN NAGS_HUMAN]] Hyperammonemia due to N-acetylglutamate synthetase deficiency. The disease is caused by mutations affecting the gene represented in this entry.
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Authors: Shi, D., Zhao, G, Jin, Z., Allewell, N.M., Tuchman, M.
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==Function==
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[[http://www.uniprot.org/uniprot/NAGS_HUMAN NAGS_HUMAN]] Plays a role in the regulation of ureagenesis by producing variable amounts of N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPSI) activity.
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Description: Structure of the N-acetyltransferase domain of human N-acetylglutamate synthase
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==About this Structure==
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[[4k30]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K30 OCA].
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==Reference==
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<ref group="xtra">PMID:023894642</ref><references group="xtra"/><references/>
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[[Category: Amino-acid N-acetyltransferase]]
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[[Category: Homo sapiens]]
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[[Category: Allewell, N M.]]
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[[Category: Jin, Z.]]
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[[Category: Shi, D.]]
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[[Category: Tuchman, M.]]
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[[Category: Zhao, G]]
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[[Category: Gcn5-ralated n-acetyltransferase fold]]
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[[Category: Synthase]]
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[[Category: Transferase]]

Revision as of 07:55, 14 August 2013

Template:STRUCTURE 4k30

Contents

Structure of the N-acetyltransferase domain of human N-acetylglutamate synthase

Template:ABSTRACT PUBMED 23894642

Disease

[NAGS_HUMAN] Hyperammonemia due to N-acetylglutamate synthetase deficiency. The disease is caused by mutations affecting the gene represented in this entry.

Function

[NAGS_HUMAN] Plays a role in the regulation of ureagenesis by producing variable amounts of N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPSI) activity.

About this Structure

4k30 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Zhao G, Jin Z, Allewell NM, Tuchman M, Shi D. Crystal structure of the N-acetyltransferase domain of human N-acetyl-L-glutamate synthase in complex with N-acetyl-L-glutamate provides insights into its catalytic and regulatory mechanisms. PLoS One. 2013 Jul 24;8(7):e70369. doi: 10.1371/journal.pone.0070369. Print 2013. PMID:23894642 doi:10.1371/journal.pone.0070369

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OCA

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