4isq

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'''Unreleased structure'''
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{{STRUCTURE_4isq| PDB=4isq | SCENE= }}
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===Binding domain of Botulinum neurotoxin DC in complex with human synaptotagmin I===
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The entry 4isq is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/SYT1_HUMAN SYT1_HUMAN]] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
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Authors: Berntsson, R.P.-A., Peng, L., Svensson, L.M., Dong, M., Stenmark, P.
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==About this Structure==
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[[4isq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ISQ OCA].
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Description: Binding domain of Botulinum neurotoxin DC in complex with human synaptotagmin I
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[[Category: Clostridium botulinum]]
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[[Category: Berntsson, R P.A.]]
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[[Category: Dong, M.]]
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[[Category: Peng, L.]]
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[[Category: Stenmark, P.]]
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[[Category: Svensson, L M.]]
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[[Category: Membrane binding]]
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[[Category: Synaptotagmin and ganglioside binding]]
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[[Category: Toxin]]

Revision as of 07:59, 14 August 2013

Template:STRUCTURE 4isq

Binding domain of Botulinum neurotoxin DC in complex with human synaptotagmin I

Function

[SYT1_HUMAN] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.

About this Structure

4isq is a 6 chain structure with sequence from Clostridium botulinum. Full crystallographic information is available from OCA.

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