This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4isq
From Proteopedia
| Line 1: | Line 1: | ||
| - | + | {{STRUCTURE_4isq| PDB=4isq | SCENE= }} | |
| + | ===Binding domain of Botulinum neurotoxin DC in complex with human synaptotagmin I=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/SYT1_HUMAN SYT1_HUMAN]] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. | ||
| - | + | ==About this Structure== | |
| - | + | [[4isq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ISQ OCA]. | |
| - | + | [[Category: Clostridium botulinum]] | |
| + | [[Category: Berntsson, R P.A.]] | ||
| + | [[Category: Dong, M.]] | ||
| + | [[Category: Peng, L.]] | ||
| + | [[Category: Stenmark, P.]] | ||
| + | [[Category: Svensson, L M.]] | ||
| + | [[Category: Membrane binding]] | ||
| + | [[Category: Synaptotagmin and ganglioside binding]] | ||
| + | [[Category: Toxin]] | ||
Revision as of 07:59, 14 August 2013
Binding domain of Botulinum neurotoxin DC in complex with human synaptotagmin I
Function
[SYT1_HUMAN] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
About this Structure
4isq is a 6 chain structure with sequence from Clostridium botulinum. Full crystallographic information is available from OCA.
