4jyk

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'''Unreleased structure'''
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{{STRUCTURE_4jyk| PDB=4jyk | SCENE= }}
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===Structure of E. coli Transcriptional Regulator RutR with bound uracil===
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The entry 4jyk is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/RUTR_ECOLI RUTR_ECOLI]] Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines. It also regulates the synthesis of pyrimidine nucleotides and arginine from glutamine (carAB) and the supply of glutamate (gadABWX).<ref>PMID:16540542</ref> <ref>PMID:17919280</ref>
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Authors: Cooper, D.R., Knapik, A.A., Petkowski, J.J., Porebski, P.J., Osinski,T., Almo, S.C., Minor, W., New York Structural Genomics Research Consortium (NYSGRC)
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==About this Structure==
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[[4jyk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JYK OCA].
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Description: Structure of E. coli Transcriptional Regulator RutR with bound uracil
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Escherichia coli k-12]]
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[[Category: Almo, S C.]]
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[[Category: Cooper, D R.]]
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[[Category: Knapik, A A.]]
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[[Category: Minor, W.]]
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[[Category: NYSGRC, New York Structural Genomics Research Consortium.]]
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[[Category: Osinski,T.]]
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[[Category: Petkowski, J J.]]
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[[Category: Porebski, P J.]]
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[[Category: Helix-turn-helix]]
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[[Category: New york structural genomics research consortium]]
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[[Category: Nysgrc]]
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[[Category: Psi-biology]]
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[[Category: Structural genomic]]
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[[Category: Transcription regulator]]
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[[Category: Transcriptional regulator]]

Revision as of 08:00, 14 August 2013

Template:STRUCTURE 4jyk

Contents

Structure of E. coli Transcriptional Regulator RutR with bound uracil

Function

[RUTR_ECOLI] Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines. It also regulates the synthesis of pyrimidine nucleotides and arginine from glutamine (carAB) and the supply of glutamate (gadABWX).[1] [2]

About this Structure

4jyk is a 2 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.

Reference

  1. ↑ Loh KD, Gyaneshwar P, Markenscoff Papadimitriou E, Fong R, Kim KS, Parales R, Zhou Z, Inwood W, Kustu S. A previously undescribed pathway for pyrimidine catabolism. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5114-9. Epub 2006 Mar 15. PMID:16540542 doi:0600521103
  2. ↑ Shimada T, Hirao K, Kori A, Yamamoto K, Ishihama A. RutR is the uracil/thymine-sensing master regulator of a set of genes for synthesis and degradation of pyrimidines. Mol Microbiol. 2007 Nov;66(3):744-57. Epub 2007 Oct 5. PMID:17919280 doi:10.1111/j.1365-2958.2007.05954.x

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