3ziq

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'''Unreleased structure'''
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{{STRUCTURE_3ziq| PDB=3ziq | SCENE= }}
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===minor-site specific NLS (B6)===
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{{ABSTRACT_PUBMED_23910026}}
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The entry 3ziq is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/IMA2_MOUSE IMA2_MOUSE]] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
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Authors: Chang, C.-W., Counago, R.M., Williams, S.J., Kobe, B.
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==About this Structure==
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[[3ziq]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZIQ OCA].
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Description: minor-site specific NLS (B6)
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==Reference==
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<ref group="xtra">PMID:023910026</ref><references group="xtra"/><references/>
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[[Category: Mus musculus]]
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[[Category: Synthetic construct]]
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[[Category: Chang, C W.]]
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[[Category: Counago, R M.]]
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[[Category: Kobe, B.]]
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[[Category: Williams, S J.]]
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[[Category: Nuclear import]]
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[[Category: Nuclear localization signal]]
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[[Category: Transport protein]]

Revision as of 08:20, 21 August 2013

Template:STRUCTURE 3ziq

Contents

minor-site specific NLS (B6)

Template:ABSTRACT PUBMED 23910026

Function

[IMA2_MOUSE] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

About this Structure

3ziq is a 3 chain structure with sequence from Mus musculus and Synthetic construct. Full crystallographic information is available from OCA.

Reference

  • Chang CW, Counago RM, Williams SJ, Boden M, Kobe B. Distinctive Conformation of Minor Site-Specific Nuclear Localization Signals Bound to Importin-alpha Traffic. 2013 Aug 2. doi: 10.1111/tra.12098. PMID:23910026 doi:10.1111/tra.12098

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OCA

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